The Emory Alcohol and Lung Biology Training Program formally began on July 1, 2002. However, its roots can be traced to 1996 when the Program leaders began their novel studies of the mechanisms by which chronic alcohol abuse renders the lung susceptible to injury. In the past decade the Program investigators have made a series of seminal observations in both clinical studies and in animal models that have revealed previously unrecognized effects of alcohol abuse on lung structure and function. Importantly, the health effects of alcohol abuse on lung disease rival or even exceed the effects on other organs considered to be the primary targets of alcohol toxicity. The goal of the Program is to train a new generation of alcohol researchers with the skills to perform cutting edge translational research, using both experimental models and clinical studies, to advance our understanding of the pathophysiology and treatment of alcohol-induced lung disease. Capitalizing on a highly collaborative group of alcohol researchers from multiple disciplines, the Program will continue to recruit promising young scientists from basic science as well as clinical training programs and provide a fertile and nurturing environment for post-doctoral MD and PhD trainees to work together. Unique aspects of the Program include a close association with Historically Black College and University (HBCU) institutions in the Atlanta area. In parallel, several key faculty mentors have leadership positions in other training programs at Emory University, allowing this Program to be highly integrated with other training programs and greatly increase the educational and training opportunities of the fellows. In addition, the Program will identify and recruit outstanding pre-doctoral minority students from Emory University and the HBCU institutions for short-term training opportunities with faculty mentors in order to increase the pool of qualified minority candidates for subsequent careers in alcohol research. Epidemiological studies by Program investigators provide new but daunting evidence that alcohol abuse has an enormous societal impact on lung health, and may cause more premature deaths, and at even younger ages, than alcoholic liver disease. Therefore, there is a compelling need for well-trained investigators with the basic and clinical research skills to perform high quality translational research with a goal of developing effective treatments that can decrease the enormous morbidity and mortality of alcohol-related lung disease. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
2T32AA013528-06
Application #
7232831
Study Section
Special Emphasis Panel (ZAA1-HH (81))
Program Officer
Gentry, Thomas
Project Start
2002-07-01
Project End
2012-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
6
Fiscal Year
2007
Total Cost
$294,287
Indirect Cost
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Han, Jenny E; Alvarez, Jessica A; Staitieh, Bashar et al. (2018) Oxidative stress in critically ill ventilated adults: effects of vitamin D3 and associations with alveolar macrophage function. Eur J Clin Nutr 72:744-751
Forrest, Osric A; Ingersoll, Sarah A; Preininger, Marcela K et al. (2018) Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosis. J Leukoc Biol 104:665-675
Han, Jenny E; Alvarez, Jessica A; Jones, Jennifer L et al. (2017) Impact of high-dose vitamin D3 on plasma free 25-hydroxyvitamin D concentrations and antimicrobial peptides in critically ill mechanically ventilated adults. Nutrition 38:102-108
Kempker, Jordan A; Magee, Matthew J; Cegielski, J Peter et al. (2016) Associations Between Vitamin D Level and Hospitalizations With and Without an Infection in a National Cohort of Medicare Beneficiaries. Am J Epidemiol 183:920-9
Schlingmann, Barbara; Overgaard, Christian E; Molina, Samuel A et al. (2016) Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions. Nat Commun 7:12276
Han, Jenny E; Jones, Jennifer L; Tangpricha, Vin et al. (2016) High Dose Vitamin D Administration in Ventilated Intensive Care Unit Patients: A Pilot Double Blind Randomized Controlled Trial. J Clin Transl Endocrinol 4:59-65
Yeligar, Samantha M; Mehta, Ashish J; Harris, Frank L et al. (2016) Peroxisome Proliferator-Activated Receptor ? Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction. Am J Respir Cell Mol Biol 55:35-46
Ward, Christina; Schlingmann, Barbara; Stecenko, Arlene A et al. (2015) NF-?B inhibitors impair lung epithelial tight junctions in the absence of inflammation. Tissue Barriers 3:e982424
Kempker, Jordan A; West, Kathryn G; Kempker, Russell R et al. (2015) Vitamin D status and the risk for hospital-acquired infections in critically ill adults: a prospective cohort study. PLoS One 10:e0122136
Overgaard, Christian E; Schlingmann, Barbara; Dorsainvil White, StevenClaude et al. (2015) The relative balance of GM-CSF and TGF-?1 regulates lung epithelial barrier function. Am J Physiol Lung Cell Mol Physiol 308:L1212-23

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