During the past decade important advances in molecular biology, genetics, bioinformatics, and imaging have provided neuroscientists with an array of powerful tools that promise to greatly advance our understanding of how this most complex of biological systems both develops and functions. Based on such understanding, cures or treatments for a wide range of disorders of the nervous system, whether resulting from disease or injury, also appear within reach for the first time. There is thus a great need to train a new generation of neuroscientists who can exploit these new tools to understand human brain function and dysfunction. The goal of this predoctoral training program is to provide students in the early stages of their training with a broad understanding of neuroscience and the technical and conceptual skills needed to identify and address the most interesting remaining questions in multidisciplinary ways. Specifically the aim is to produce students who can creatively apply modern molecular, genetic, and biophysical/imaging approaches toward understanding how the nervous system develops, functions, and responds to injury or disease. This will be achieved by a program of formal course work and laboratory rotations during the first two years, and even more importantly by a program of active, continuous self-learning through participation in journal clubs and other forums, outside seminars, and a yearly neurosciences retreat throughout their training.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
2T32AG000271-06
Application #
6749799
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (J2))
Program Officer
Wise, Bradley C
Project Start
1999-09-01
Project End
2009-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
6
Fiscal Year
2004
Total Cost
$193,451
Indirect Cost
Name
Case Western Reserve University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Sears, James C; Broihier, Heather T (2016) FoxO regulates microtubule dynamics and polarity to promote dendrite branching in Drosophila sensory neurons. Dev Biol 418:40-54
McLaughlin, Colleen N; Nechipurenko, Inna V; Liu, Nan et al. (2016) A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons. J Cell Biol 214:459-74
Youngstrom, Isaac A; Strowbridge, Ben W (2012) Visual landmarks facilitate rodent spatial navigation in virtual reality environments. Learn Mem 19:84-90
James, Rebecca E; Broihier, Heather T (2011) Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction. Development 138:3273-86
Busch, Sarah A; Hamilton, Jason A; Horn, Kevin P et al. (2011) Multipotent adult progenitor cells prevent macrophage-mediated axonal dieback and promote regrowth after spinal cord injury. J Neurosci 31:944-53
Oh, Eugene; Maejima, Takashi; Liu, Chen et al. (2010) Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. J Biol Chem 285:30825-36
Busch, Sarah A; Horn, Kevin P; Cuascut, Fernando X et al. (2010) Adult NG2+ cells are permissive to neurite outgrowth and stabilize sensory axons during macrophage-induced axonal dieback after spinal cord injury. J Neurosci 30:255-65
Busch, Sarah A; Horn, Kevin P; Silver, Daniel J et al. (2009) Overcoming macrophage-mediated axonal dieback following CNS injury. J Neurosci 29:9967-76
Larimer, Phillip; Strowbridge, Ben W (2008) Nonrandom local circuits in the dentate gyrus. J Neurosci 28:12212-23
Horn, Kevin P; Busch, Sarah A; Hawthorne, Alicia L et al. (2008) Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions. J Neurosci 28:9330-41

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