Infectious diseases are a major cause of morbidity, mortality and loss of economic productivity worldwide. Microbial drug resistance, emerging infections, use of microbes as bioterrorism weapons, and acquired immunodeficiency syndrome (AIDS) are examples of currently unsolved infectious disease problems. Developing improved methods to diagnose, treat and prevent infectious diseases and bioterrorism is a high national priority, and achieving that goal will require training additional scientists with expertise in microbial pathogenesis. This is the first competing renewal application for our postdoctoral training program on the Molecular Basis of Microbial Pathogenesis at the University of Colorado Health Sciences Center. Our training faculty currently consists of 18 highly interactive scientists from the Departments of Biochemistry and Molecular Genetics, Medicine, Microbiology, Neurology, Pediatrics and Pharmacology. They have outstanding NIH-funded research programs on microbial pathogenesis, documented success with postdoctoral-level training, extensive professional interactions, and excellent research facilities. Our program provides interdisciplinary, laboratory-based training on the molecular basis of microbial pathogenesis for basic biomedical scientists and physician-scientists. Our trainees supplement their laboratory research by taking advanced graduate-level courses in relevant basic biomedical sciences and scientific ethics, participating in a wide variety of seminars, journal clubs and data clubs, and attending national scientific meetings to present their research findings and interact with experts in their research areas. Major strengths of our program include the increasing size of our training faculty and the breadth of their interdisciplinary expertise, the increasing pool of eligible applicants and the high quality of the admitted trainees, the broad range of training activities, and the extensive interactions between our trainees and faculty members with Ph.D., M.D., and D.V.M. training. We will recruit actively for qualified trainees from under-represented minority groups. Most of our previous postdoctoral trainees are now successful research scientists in academia, government or the biotechnology/pharmaceutical industry.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI007537-06
Application #
6659594
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Mcsweegan, Edward
Project Start
1998-09-30
Project End
2008-08-31
Budget Start
2003-09-15
Budget End
2004-08-31
Support Year
6
Fiscal Year
2003
Total Cost
$153,328
Indirect Cost
Name
University of Colorado Denver
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Lee, Katherine S; Suarez, Andrea L; Claypool, David J et al. (2012) Viral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclins. PLoS Pathog 8:e1002496
Lee, Katherine S; Groshong, Steve D; Cool, Carlyne D et al. (2009) Murine gammaherpesvirus 68 infection of IFNgamma unresponsive mice: a small animal model for gammaherpesvirus-associated B-cell lymphoproliferative disease. Cancer Res 69:5481-9
Clarke, Penny; Tyler, Kenneth L (2009) Apoptosis in animal models of virus-induced disease. Nat Rev Microbiol 7:144-55
Lee, Katherine S; Cool, Carlyne D; van Dyk, Linda F (2009) Murine gammaherpesvirus 68 infection of gamma interferon-deficient mice on a BALB/c background results in acute lethal pneumonia that is dependent on specific viral genes. J Virol 83:11397-401
Davis, Larry E; Beckham, J David; Tyler, Kenneth L (2008) North American encephalitic arboviruses. Neurol Clin 26:727-57, ix
Kempf, Brian J; Barton, David J (2008) Poliovirus 2A(Pro) increases viral mRNA and polysome stability coordinately in time with cleavage of eIF4G. J Virol 82:5847-59
White, Tiffany; Hagen, Moira; Gudza, Ivy et al. (2008) Genetic diversity of the Kaposi's sarcoma herpesvirus K1 protein in AIDS-KS in Zimbabwe. J Clin Virol 42:165-71
Kempf, Brian J; Barton, David J (2008) Poly(rC) binding proteins and the 5'cloverleaf of uncapped poliovirus mRNA function during de novo assembly of polysomes. J Virol 82:5835-46
Beckham, J David; Goody, Robin J; Clarke, Penny et al. (2007) Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase. J Virol 81:6984-92
Chromy, Laura R; Oltman, Amy; Estes, Patricia A et al. (2006) Chaperone-mediated in vitro disassembly of polyoma- and papillomaviruses. J Virol 80:5086-91

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