Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007608-04
Application #
6756020
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2001-09-01
Project End
2006-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
4
Fiscal Year
2004
Total Cost
$115,499
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Klinkenberg, Lee G; Sutherland, Lesley A; Bishai, William R et al. (2008) Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency. J Infect Dis 198:275-83
Page, Kathleen R; Manabe, Yukari C; Adelakun, Akintoye et al. (2008) Timing of therapy for latent tuberculosis infection among immigrants presenting to a U.S. public health clinic: a retrospective study. BMC Public Health 8:158
Page, Kathleen R; Sifakis, Frangiscos; Montes de Oca, Ruben et al. (2006) Improved adherence and less toxicity with rifampin vs isoniazid for treatment of latent tuberculosis: a retrospective study. Arch Intern Med 166:1863-70
Wade, Mary Margaret; Zhang, Ying (2006) Effects of weak acids, UV and proton motive force inhibitors on pyrazinamide activity against Mycobacterium tuberculosis in vitro. J Antimicrob Chemother 58:936-41
Karakousis, Petros C; Yoshimatsu, Tetsuyuki; Lamichhane, Gyanu et al. (2004) Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice. J Exp Med 200:647-57
Wade, Mary Margaret; Zhang, Ying (2004) Mechanisms of drug resistance in Mycobacterium tuberculosis. Front Biosci 9:975-94
Wade, Mary Margaret; Zhang, Ying (2004) Anaerobic incubation conditions enhance pyrazinamide activity against Mycobacterium tuberculosis. J Med Microbiol 53:769-73
Karakousis, Petros C; Moore, Richard D; Chaisson, Richard E (2004) Mycobacterium avium complex in patients with HIV infection in the era of highly active antiretroviral therapy. Lancet Infect Dis 4:557-65
Zhang, Ying; Wade, Mary Margaret; Scorpio, Angelo et al. (2003) Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid. J Antimicrob Chemother 52:790-5