The purpose of this program is to provide strong and comprehensive predoctoral and postdoctoral training in parasitology, with a particular emphasis on immunoparasitology. The program contains a strong foundation in coursework with research experience utilizing either metazoan (helminth) or protozoan parasites. All trainees will take core courses in parasitology in addition to advanced courses in other essential disciplines such as immunology, molecular biology and biochemistry. In addition, a course on Ethical Issues and Professional Responsibilities is mandatory as is participation in the Microbiology and Immunology seminar series, a journal club and a parasitology ?Works-in-progress? monthly meeting. A one day spring symposium with a prominent invited speaker will be included as a part of this training program. Graduate student entry and training will be administered through the Field of Comparative Biomedical Science and the Field of Immunology. Thesis research will be performed in one of the eight laboratories of the participating faculty, all of whom have appointments within the College of Veterinary Medicine. Areas available for training are centered on an analysis of immunity to helminth (trematode and nematode) parasites present at various sites in the body. Additionally, four laboratories use protozoan parasites as the principal target organism of investigation. While a major theme has been immunity to these agents, the host parasite interaction, parasite biology and the development of vaccines are also significant components of several participants? research. In addition to basic studies using sophisticated contemporary mouse (knockout and mutant) models, host species being examined include rats, fish and horses thus ensuring students benefit from a broad exposure to the diverse nature of parasitic disease. Existing support for the program is substantial in the form of research environment and facilities, the Cornell Biotechnology Program and computing and library systems

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007643-04
Application #
6751303
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2001-08-01
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
4
Fiscal Year
2004
Total Cost
$73,429
Indirect Cost
Name
Cornell University
Department
Microbiology/Immun/Virology
Type
Schools of Veterinary Medicine
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Bassity, Elizabeth; Clark, Theodore G (2012) Functional identification of dendritic cells in the teleost model, rainbow trout (Oncorhynchus mykiss). PLoS One 7:e33196
Fabre, M V; Beiting, D P; Bliss, S K et al. (2009) Immunity to Trichinella spiralis muscle infection. Vet Parasitol 159:245-8
Bierly, Allison L; Shufesky, William J; Sukhumavasi, Woraporn et al. (2008) Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection. J Immunol 181:8485-91
Egan, Charlotte E; Sukhumavasi, Woraporn; Bierly, Allison L et al. (2008) Understanding the multiple functions of Gr-1(+) cell subpopulations during microbial infection. Immunol Res 40:35-48
Beiting, Daniel P; Gagliardo, Lucille F; Hesse, Matthias et al. (2007) Coordinated control of immunity to muscle stage Trichinella spiralis by IL-10, regulatory T cells, and TGF-beta. J Immunol 178:1039-47
Leifer, Cynthia A; Brooks, James C; Hoelzer, Karin et al. (2006) Cytoplasmic targeting motifs control localization of toll-like receptor 9. J Biol Chem 281:35585-92
Beiting, Daniel P; Park, Pyong Woo; Appleton, Judith A (2006) Synthesis of syndecan-1 by skeletal muscle cells is an early response to infection with Trichinella spiralis but is not essential for nurse cell development. Infect Immun 74:1941-3
Beiting, Daniel P; Bliss, Susan K; Schlafer, Donald H et al. (2004) Interleukin-10 limits local and body cavity inflammation during infection with muscle-stage Trichinella spiralis. Infect Immun 72:3129-37