This application for a postgraduate research training program in Cellular and Molecular Microbiology is submitted by a group of investigators who are on the faculty of Vanderbilt University (VU) and Meharry Medical College (MMC). The training program grew out of a coalescence of two disciplines, molecular microbiology and cell biology, and is an attempt to bring together many basic scientists at VU and MMC who work in areas germane to a new field of cellular microbiology and are committed to training postdoctoral fellows to be supported by the Institutional NRSA. The novel aspects of the training program consist of an emphasis on the state of the art cell biology as applied to the study of model organisms in the following areas: (i) Microbial Adhesion; (ii) Cytoskeleton and Cytokinesis; (iii) Endocytosis/Lysosomal Pathway; (iv) Signal Transduction/Gene Transcription; (v) RNA Binding Proteins; (vi) Proteosomes-ER-Golgi Pathway; (vii) Apoptosis and Mitochondrial Function; (viii) Virus-Cell Interaction; (ix) Molecular Genetics of Recombination, Mutations, and Microbial Diversity; and (x) New Technologies of Cell Imaging, Subcellular Targeting, and Proteomics. The postdoctoral trainees will be selected by the Steering Committee from PhD and/or MD/PhD graduates who wish to specialize in Cellular Microbiology and who apply directly to the Program as well as those nominated by the faculty preceptors. Funds are also requested for five summer students. Special attention has been paid to a stringent selection process, adequate mentoring by excellent preceptors including an innovative dual mentoring system, promoting scientific interactions between participating laboratories, and career counseling. Cumulatively, this new program will take full advantage of the superb resources at VU and MMC in terms of faculty and available trainees to provide an optimally effective and innovative postgraduate training in the new field of cellular microbiology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI049824-02
Application #
6511584
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2001-08-01
Project End
2006-07-31
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
2
Fiscal Year
2002
Total Cost
$185,235
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Sethman, Chad R; Hawiger, Jacek (2013) The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling. PLoS One 8:e70994
Danthi, Pranav; Holm, Geoffrey H; Stehle, Thilo et al. (2013) Reovirus receptors, cell entry, and proapoptotic signaling. Adv Exp Med Biol 790:42-71
Denison, Mark R; Graham, Rachel L; Donaldson, Eric F et al. (2011) Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. RNA Biol 8:270-9
Holm, Geoffrey H; Pruijssers, Andrea J; Li, Lianna et al. (2010) Interferon regulatory factor 3 attenuates reovirus myocarditis and contributes to viral clearance. J Virol 84:6900-8
Danthi, Pranav; Pruijssers, Andrea J; Berger, Angela K et al. (2010) Bid regulates the pathogenesis of neurotropic reovirus. PLoS Pathog 6:e1000980
Eckerle, Lance D; Becker, Michelle M; Halpin, Rebecca A et al. (2010) Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. PLoS Pathog 6:e1000896
Zurney, Jennifer; Kobayashi, Takeshi; Holm, Geoffrey H et al. (2009) Reovirus mu2 protein inhibits interferon signaling through a novel mechanism involving nuclear accumulation of interferon regulatory factor 9. J Virol 83:2178-87
Danthi, Pranav; Kobayashi, Takeshi; Holm, Geoffrey H et al. (2008) Reovirus apoptosis and virulence are regulated by host cell membrane penetration efficiency. J Virol 82:161-72
Kobayashi, Takeshi; Antar, Annukka A R; Boehme, Karl W et al. (2007) A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe 1:147-57
Eckerle, Lance D; Lu, Xiaotao; Sperry, Steven M et al. (2007) High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants. J Virol 81:12135-44

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