The anthrax bioemergency following the 9/11 terrorist attack forced us to recognize the menace of infectious organisms as biological weapons. Preparedness in response to infectious threats requires individuals well versed in bioterrorism and infectious diseases, as was demonstrated by Wadsworth Center's anthrax testing initiative in 2001. To further meet this need, a training program is proposed for biodefense and emerging infection research for predoctoral and postdoctoral fellows in the laboratory sciences with an enrichment component in epidemiology. The goal of this program is to provide multi-disciplinary training combining basic and applied research to produce: (1) doctoral graduates with backgrounds in biodefense and emerging infectious diseases; and, (2) postdoctoral fellows who can become independent scientists developing integrated research programs in biodefense and emerging infections. Thirteen well-funded mentors are drawn from the Wadsworth Center and the Division of Epidemiology of the New York State Department of Health, through their academic appointments within the School of Public Health, State University of New York at Albany (SUNYA -SPH). This unique training environment combines fundamental research with biodefense and infectious disease outbreak response. The training program's key components are based on the existing curriculum of the Department of Biomedical Sciences and incorporate specific courses from the Department of Epidemiology. The didactic components include grounding in biochemistry, cell biology, microbiology, virology, molecular genetics, microbial pathogenesis and immunology. The epidemiological enrichment provides an emphasis on the biological basis of public health, statistical inference, disease transmission, and data management. The Biodefense Sciences course introduces biosafety procedures, pathogen containment, pathogen detection, and bioterrorism event and response modeling. Fellows will participate in clinically relevant laboratory rotations and colloquia, and journal clubs covering advanced topics and the current literature. A biodefense research seminar series will build on existing Wadsworth Center and Department of Health seminar programs. The steering and advisory committees, and the existing SUNYA-SPH academic structures, ensure that high-quality applicants enter this specialized program and that both pre-and postdoctoral students become productive scientists in this research area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI055429-03
Application #
7093554
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Garges, Susan
Project Start
2004-07-01
Project End
2009-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
3
Fiscal Year
2006
Total Cost
$218,763
Indirect Cost
Name
Wadsworth Center
Department
Type
DUNS #
153695478
City
Menands
State
NY
Country
United States
Zip Code
12204
Girardin, Roxie C; Bai, Guangchun; He, Jie et al. (2018) AbmR (Rv1265) is a novel transcription factor of Mycobacterium tuberculosis that regulates host cell association and expression of the non-coding small RNA Mcr11. Mol Microbiol 110:811-830
Kelley, Danielle S; Lennon, Christopher W; Li, Zhong et al. (2018) Mycobacterial DnaB helicase intein as oxidative stress sensor. Nat Commun 9:4363
Fitzgerald, Devon M; Smith, Carol; Lapierre, Pascal et al. (2018) The evolutionary impact of intragenic FliA promoters in proteobacteria. Mol Microbiol 108:361-378
Li, Zhong; Sakamuru, Srilatha; Huang, Ruili et al. (2018) Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease. Antiviral Res 150:217-225
Li, Zhong; Brecher, Matthew; Deng, Yong-Qiang et al. (2017) Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction. Cell Res 27:1046-1064
Johnson, Richard M; Bai, Guangchun; DeMott, Christopher M et al. (2017) Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling. Mol Microbiol 105:294-308
Kelley, Danielle S; Lennon, Christopher W; SEA-PHAGES et al. (2016) Mycobacteriophages as Incubators for Intein Dissemination and Evolution. MBio 7:
Levinson, Kara J; Baranova, Danielle E; Mantis, Nicholas J (2016) A monoclonal antibody that targets the conserved core/lipid A region of lipopolysaccharide affects motility and reduces intestinal colonization of both classical and El Tor Vibrio cholerae biotypes. Vaccine 34:5833-5836
Van Slyke, Greta; Sully, Erin K; Bohorova, Natasha et al. (2016) Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge. Clin Vaccine Immunol 23:795-9
Yermakova, Anastasiya; Klokk, Tove Irene; O'Hara, Joanne M et al. (2016) Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin's Enzymatic Subunit Interfere with Intracellular Toxin Transport. Sci Rep 6:22721

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