The Nebraska Center for Virology proposes the development and institutionalization of a training program that will further strengthen its ongoing research and training activities. This program will generate biomedical researchers equipped to lend their expertise to infectious viral diseases and to apply their newly acquired knowledge and skills to research, biodefense readiness, and public health and related activities. The program will train pre-doctoral students and postdoctoral fellows in the pathogenesis of emerging and re-emerging viral diseases of humans, animals and plants. Four pre-doctoral and two postdoctoral positions will be created, with one pre-doctoral and one postdoctoral position being reserved for applicants from underrepresented groups. Eleven well-funded and experienced researchers from the University of Nebraska-Lincoln's School of Biological Sciences and Department of Veterinary and Biomedical Sciences, and the University of Nebraska Medical Center's Department of Oral Biology and Department of Pathology and Microbiology will serve as faculty trainers. Long-Range Goal: Develop a strong cadre of junior scientists and investigators who are well rounded in fundamental knowledge in virology and laboratory research, allowing them to confront current and future viral infectious diseases that may emerge. Objectives: 1) Attract top-ranked students to pursue a research career in comparative virology; 2) Provide a structured training program and stimulating research experiences for graduate students and postdoctoral fellows.
Specific Aims : 1) Establish a fellowship program to enhance recruitment and retention of pre-doctoral students to the Ph.D. program in microbiology with a major emphasis in virology at the University of Nebraska and 2) Develop and provide postdoctoral training in basic viral pathogenesis through the Nebraska Center for Virology. The Center has the infrastructure, expertise and facilities to manage the proposed program and achieve its goal to become a national center for research and training of biomedical researchers in emerging and reemerging viral diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI060547-05
Application #
7470066
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2004-09-01
Project End
2009-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
5
Fiscal Year
2008
Total Cost
$247,440
Indirect Cost
Name
University of Nebraska Lincoln
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
555456995
City
Lincoln
State
NE
Country
United States
Zip Code
68588
Olp, Landon N; Minhas, Veenu; Gondwe, Clement et al. (2016) Longitudinal analysis of the humoral response to Kaposi's sarcoma-associated herpesvirus after primary infection in children. J Med Virol 88:1973-81
Olp, Landon N; Jeanniard, Adrien; Marimo, Clemence et al. (2015) Whole-Genome Sequencing of Kaposi's Sarcoma-Associated Herpesvirus from Zambian Kaposi's Sarcoma Biopsy Specimens Reveals Unique Viral Diversity. J Virol 89:12299-308
Wang, Lin-Xu; Mellon, Michael; Bowder, Dane et al. (2015) Escherichia coli surface display of single-chain antibody VRC01 against HIV-1 infection. Virology 475:179-86
Jamin, Augusta; Wiebe, Matthew S (2015) Barrier to Autointegration Factor (BANF1): interwoven roles in nuclear structure, genome integrity, innate immunity, stress responses and progeria. Curr Opin Cell Biol 34:61-8
Olp, Landon N; Minhas, Veenu; Gondwe, Clement et al. (2015) Effects of Antiretroviral Therapy on Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Transmission Among HIV-Infected Zambian Children. J Natl Cancer Inst 107:
Moore, Tyler C; Vogel, Alexander J; Petro, Thomas M et al. (2015) IRF3 deficiency impacts granzyme B expression and maintenance of memory T cell function in response to viral infection. Microbes Infect 17:426-39
Crabtree, Kay L; Wojcicki, Janet M; Minhas, Veenu et al. (2014) Risk factors for early childhood infection of human herpesvirus-8 in Zambian children: the role of early childhood feeding practices. Cancer Epidemiol Biomarkers Prev 23:300-8
Noel, Eric A; Kang, Ming; Adamec, Jiri et al. (2014) Chlorovirus Skp1-binding ankyrin repeat protein interplay and mimicry of cellular ubiquitin ligase machinery. J Virol 88:13798-810
Jamin, Augusta; Wicklund, April; Wiebe, Matthew S (2014) Cell- and virus-mediated regulation of the barrier-to-autointegration factor's phosphorylation state controls its DNA binding, dimerization, subcellular localization, and antipoxviral activity. J Virol 88:5342-55
Workman, Aspen M; Jacobs, Ashley K; Vogel, Alexander J et al. (2014) Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells. PLoS One 9:e89010

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