The goal of this T32-supported program is to train Infectious Diseases MD or MD/PhD postdoctoral fellows at University of California Los Angeles (UCLA) in translational pathogenesis research in HIV-1 and other viral diseases. With a huge global disease burden of viral diseases (such as HIV-1 and viral hepatitis C) and increasing basic scientific research, a key bottleneck for developing successful therapies and vaccines is translational research. There is therefore a pressing need for qualified physician-scientist researchers who can work from bench to bedside. Given the overall strength of UCLA in translational/basic HIV-1 research and basic virology research, our training program is predominately focused on HIV-1, with opportunities for fellows to pursue translational pathogenesis studies on other viruses as well. We have assembled a highly selected group of faculty members to serve as potential mentors, spanning several UCLA departments. Trainees are encouraged to take full advantage of the numerous collaborations between participating basic science and clinical faculty in order to create unique translational research opportunities. Research mentors have active IRB protocols to recruit subjects for the study of HIV and HCV pathogenesis, are actively involved with human trials for novel antiviral therapeutics, and are studying virtually all aspects of HIV-1 pathogenesis. Many faculty mentors are also studying fundamental virology of other viruses such as Hepatitis C Virus and Herpesviruses. Our program supports MD trainees (leading to a PhD) or MD/PhD trainees (seeking formal postdoctoral training) as part of their Infectious Diseases subspecialty training, with significant contribution from the Department of Medicine Specialty Training in Advanced Research (STAR) Program that provides structured scientific and career training. This T32 training program supports one well-qualified trainee each year. We provide trainees with significant protected research time so that they may develop independent research interests and secure independent funding. The ultimate goal of this training program is for all our trainees to succeed as independent investigators. The first three years supported by this T32 have demonstrated our success in drawing quality physician trainees and providing them with the outstanding environment and resources to develop academic careers in basic translational virologic research.

Public Health Relevance

This training grant supports the development of new physician-scientists who can bridge the gap between the laboratory and the bedside, and increases in the number of well-qualified individuals studying AIDS and other chronic viral diseases. This is crucial to bringing the rapidly expanding world of basic scientific discoveries t the benefit of patients with chronic viral infections.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI089398-06
Application #
8789742
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
Project Start
2010-05-15
Project End
2020-07-31
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
6
Fiscal Year
2015
Total Cost
$204,900
Indirect Cost
$14,178
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Gaufin, Thaidra; Tobin, Nicole H; Aldrovandi, Grace M (2018) The importance of the microbiome in pediatrics and pediatric infectious diseases. Curr Opin Pediatr 30:117-124
Quanquin, Natalie; Wang, Lulan; Cheng, Genhong (2017) Potential for treatment and a Zika virus vaccine. Curr Opin Pediatr 29:114-121
Fulcher, Jennifer A; Romas, Laura; Hoffman, Jennifer C et al. (2017) Highly Human Immunodeficiency Virus-Exposed Seronegative Men Have Lower Mucosal Innate Immune Reactivity. AIDS Res Hum Retroviruses 33:788-795
Lugo, Debra; Krogstad, Paul (2016) Enteroviruses in the early 21st century: new manifestations and challenges. Curr Opin Pediatr 28:107-13
Wollersheim, Susan K; Humphries, Romney M; Cherry, James D et al. (2015) Serological misdiagnosis of acute liver failure associated with echovirus 25 due to immunological similarities to hepatitis A virus and prozone effect. J Clin Microbiol 53:309-10
Kim, Joseph Y; Balamurugan, Arumugam; Azari, Kodi et al. (2015) Clonal CD8+ T Cell Persistence and Variable Gene Usage Bias in a Human Transplanted Hand. PLoS One 10:e0136235
Mach, Albert J; Adeyiga, Oladunni B; Di Carlo, Dino (2013) Microfluidic sample preparation for diagnostic cytopathology. Lab Chip 13:1011-26
Sigal, Alex; Kim, Jocelyn T; Balazs, Alejandro B et al. (2011) Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature 477:95-8