The goal of the Immunology Training Program (ITP) Leadership Track is to train PhD and MD/PhD scientists for outstanding careers in immunology-related research with an emphasis on developing the next generation of investigative group leaders for academia and industry (pharmaceuticals and biotechnology) alike. The program includes a wide range of Immunology-related topics, spanning from basic research in areas such as innate immunity, T cell activation, tolerance, antigen processing and presentation, MHC function, complement, antibody structure and function, and mucosal immunity to research in clinically relevant models of infectious diseases (e.g. tuberculosis, HIV), vaccine development, immunopathology, transplantation and autoimmunity. Participating departments provide a rich confluence of basic science, clinical activities and resources, and career development workshops to enrich the training of PhD students as they engage in basic and/or translational research in the field of immunology. To accomplish these training goals, the ITP Leadership Track has been developed as division of the broader ITP, itself a track within the Pathology Graduate Program. Training for the PhD degree in the program includes course work, research rotations, formal and informal seminars, a Thesis Proposal Defense/Qualifying Examination, research experience resulting in scholarly publications, career development activities and a PhD dissertation. Trainers and research laboratories are located in multiple departments at Case School of Medicine and its affiliated institutions, University Hospitals Case Medical Center (UHCMC), the Cleveland Clinic Foundation (CCF, including the Lerner Research Institute) and the Louis Stokes VA Medical Center (VAMC). The extensive inter-departmental and inter- institutional participation is underscored by explicit co-sponsorship of the ITP by the CWRU Department of Pathology, CCF Department of Immunology, CWRU/UHCMC Division of Infectious Diseases, CWRU Center for Global Health and CWRU/UHCMC Visual Sciences Research Center. Other ITP trainers are located in a wide number of other departments at Case, CCF, UHCMC, MHMC and VAMC. Regardless of their primary affiliation, ITP Trainers hold faculty or trainer appointments in the Case Department of Pathology, thereby forming a cohesive group of mentors to ensure the highest possible training environment for all program trainees.

Public Health Relevance

The Immunology Training Program Leadership Track provides PhD training to produce future group leaders in academia and industrial (pharmaceutical and biotechnology) settings who will drive important biomedical research efforts in Immunology and Immunology-related areas of clinical importance, such as infectious diseases, vaccine development, and organ transplantation autoimmunity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI089474-06A1
Application #
9150787
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Gondre-Lewis, Timothy A
Project Start
2010-05-15
Project End
2021-05-31
Budget Start
2016-06-22
Budget End
2017-05-31
Support Year
6
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Tsuda, Hidetoshi; Su, Charles A; Tanaka, Toshiaki et al. (2018) Allograft dendritic cell p40 homodimers activate donor-reactive memory CD8+ T cells. JCI Insight 3:
Shukla, Supriya; Richardson, Edward T; Drage, Michael G et al. (2018) Mycobacterium tuberculosis Lipoprotein and Lipoglycan Binding to Toll-Like Receptor 2 Correlates with Agonist Activity and Functional Outcomes. Infect Immun 86:
Johnson, Jenny L; Jones, Mark B; Cobb, Brian A (2018) Polysaccharide-experienced effector T cells induce IL-10 in FoxP3+ regulatory T cells to prevent pulmonary inflammation. Glycobiology 28:50-58
Chirieleison, Steven M; Rathkey, Joseph K; Abbott, Derek W (2018) Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity. Sci Signal 11:
Zhou, Julie Y; Oswald, Douglas M; Oliva, Kelsey D et al. (2018) The Glycoscience of Immunity. Trends Immunol 39:523-535
Athman, Jaffre J; Sande, Obondo J; Groft, Sarah G et al. (2017) Mycobacterium tuberculosis Membrane Vesicles Inhibit T Cell Activation. J Immunol 198:2028-2037
Chirieleison, Steven M; Marsh, Rebecca A; Kumar, Prathna et al. (2017) Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease. J Biol Chem 292:9666-9679
Portillo, Jose-Andres C; Muniz-Feliciano, Luis; Lopez Corcino, Yalitza et al. (2017) Toxoplasma gondii induces FAK-Src-STAT3 signaling during infection of host cells that prevents parasite targeting by autophagy. PLoS Pathog 13:e1006671
Jun, Janice C; Jones, Mark B; Oswald, Douglas M et al. (2017) T cell-intrinsic TLR2 stimulation promotes IL-10 expression and suppressive activity by CD45RbHi T cells. PLoS One 12:e0180688
Rathkey, Joseph K; Benson, Bryan L; Chirieleison, Steven M et al. (2017) Live-cell visualization of gasdermin D-driven pyroptotic cell death. J Biol Chem 292:14649-14658

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