Physical inactivity is a major cause of preventable morbidity and premature death in theU.S. Enhanced physical activity helps build and maintain healthy bones, muscles and joints, prevent joint swelling and soreness from arthritis, helps sustain independent living, and reduces the risk of developing diabetes, obesity, ischemic heart disease, dyslipidemia, and hypertension. Little is known about the mechanisms responsible for these benefits but they appear to be realized through complex interactions among molecules, cells, and systems. Understanding these mechanisms requires an integrative approach because of the encompassing responses caused by physical activity. Driven by these factors, we have designed this training program to prepare independent investigators interested in evaluating how activity/inactivity impacts function/dysfunction at all levels of inquiry. We employ multidisciplinary training experiences that include research in gene regulation, cell physiology, bio- chemistry, systems physiology, whole body responses and patient assessment and intervention. Trainees can use reductionist approaches of molecular and cell physiology to apply to the integrated responses of the whole and relate their implications to health and disease. This is achieved by 24 faculty appointed in Biomedical Sciences, Physiology, Internal Medicine, Nutritional Sciences, Physical Therapy, and the School of Nursing. There is excellent University support for this program with targeted recruitments in the area of activity/inactivity and health. Existing interactions among faculty include collaborations in research, trainee mentoring, and grant awards. All participating faculty maintain active research programs that are supported by over 58 nationally competitive grants contributing to >$10.7 M/yr direct costs of research support. Currently 34 predoctoral and 14 post- doctoral trainees are being mentored by the participating faculty. A majority of predoctoral trainees come to the program to study with specific faculty. Predoctoral trainees will work in four departmental graduate programs with degree requirements that facilitate specialized training related toactivity/ inactivity. Four predoctoral and four postdoctoral trainees are requested for the years of this renewal. Management of the training program is by the Director, Assistant Director and an Advisor Committee comprised of four faculty members representing the breadth of research approaches. The success of this program is marked by the achievements of previous trainees who have excelled in research careers in university settings.

Public Health Relevance

(Seeinstructions): Physical inactivity is a major cause of preventable morbidity and prematuredeath in the U.S. Enhanced physical activity helps build and maintain healthy bones, muscles and joints, preventjoint swelling and soreness from arthritis, helps sustain independent living, and reduces the risk of developingdiabetes, obesity, ischemic heart disease,dyslipidemia, and hypertension. This programwill train young investigators to evaluate how activity/inactivity impacts function/dysfunction and relate this to health and disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR048523-10
Application #
8495047
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Boyce, Amanda T
Project Start
2002-06-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$243,570
Indirect Cost
$19,532
Name
University of Missouri-Columbia
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
153890272
City
Columbia
State
MO
Country
United States
Zip Code
65211
Credeur, Daniel P; Reynolds, Leryn J; Holwerda, Seth W et al. (2018) Influence of physical inactivity on arterial compliance during a glucose challenge. Exp Physiol 103:483-494
Fletcher, Justin A; Linden, Melissa A; Sheldon, Ryan D et al. (2018) Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor ? coactivator-1?-deficient mice. Exp Physiol 103:408-418
Padilla, Jaume; Thorne, Pamela K; Martin, Jeffrey S et al. (2017) Transcriptomic effects of metformin in skeletal muscle arteries of obese insulin-resistant rats. Exp Biol Med (Maywood) 242:617-624
Reynolds, Leryn J; Credeur, Daniel P; Manrique, Camila et al. (2017) Obesity, type 2 diabetes, and impaired insulin-stimulated blood flow: role of skeletal muscle NO synthase and endothelin-1. J Appl Physiol (1985) 122:38-47
Porter, Jay W; Rowles 3rd, Joe L; Fletcher, Justin A et al. (2017) Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21. J Endocrinol 235:97-109
Matthew Morris, E; Meers, Grace M E; Koch, Lauren G et al. (2016) Increased aerobic capacity reduces susceptibility to acute high-fat diet-induced weight gain. Obesity (Silver Spring) 24:1929-37
Linden, Melissa A; Fletcher, Justin A; Meers, Grace M et al. (2016) A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. Am J Physiol Gastrointest Liver Physiol 311:G387-95
Morris, E Matthew; Meers, Grace M E; Koch, Lauren G et al. (2016) Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis. Am J Physiol Endocrinol Metab 311:E749-E760
Heden, Timothy D; Liu, Ying; Kanaley, Jill A (2016) Impact of Exercise Timing on Appetite Regulation in Individuals with Type 2 Diabetes. Med Sci Sports Exerc 48:182-9
Abraham, Kirk A; Kearney, Monica L; Reynolds, Leryn J et al. (2016) Red wine enhances glucose-dependent insulinotropic peptide (GIP) and insulin responses in type 2 diabetes during an oral glucose tolerance test. Diabetol Int 7:173-180

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