The training faculty are from the Departments of Biochemistry, Environmental Health Sciences, and Reproduction Biology of John Hopkins School of Hygiene and Public Health; and from the Department of Oncology of the John Hopkins School of Medicine. The Academic and administrative base for the training program is the Department of Biochemistry. The research training in the areas of chemistry and function of nucleic acids; damage to DNA by carcinogens and environmental agents; relationship of DNA repair to cancer, replication and recombination of cellular organelles and their remodeling; control of gene expression; signal transduction circuits and their control elements. Apoptosis and cell death, and epigenetic changes to the genome and gene silencing, represent emerging research themes. These areas combine to provide the educational foundation for modern investigators in the cancer fold.
| Abraham, Rachy; Hauer, Debra; McPherson, Robert Lyle et al. (2018) ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. Proc Natl Acad Sci U S A 115:E10457-E10466 |
| Jacob, Justin T; Coulombe, Pierre A; Kwan, Raymond et al. (2018) Types I and II Keratin Intermediate Filaments. Cold Spring Harb Perspect Biol 10: |
| Armstrong, Alissa R; Drummond-Barbosa, Daniela (2018) Insulin signaling acts in adult adipocytes via GSK-3? and independently of FOXO to control Drosophila female germline stem cell numbers. Dev Biol 440:31-39 |
| Leung, Anthony K L; McPherson, Robert Lyle; Griffin, Diane E (2018) Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases. PLoS Pathog 14:e1006864 |
| Lee, Christine C; Li, Bing; Yu, Hongtao et al. (2018) Sumoylation promotes optimal APC/C Activation and Timely Anaphase. Elife 7: |
| Zhang, Tao; Wu, Yen-Ching; Mullane, Patrick et al. (2018) FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Mol Cell 69:787-801.e8 |
| Abraham, Rachy; McPherson, Robert Lyle; Sreekumar, Easwaran et al. (2018) Preparation of Recombinant Alphaviruses for Functional Studies of ADP-Ribosylation. Methods Mol Biol 1813:297-316 |
| Zieman, Abigail; Coulombe, Pierre A (2018) The keratin 16 null phenotype is modestly impacted by genetic strain background in mice. Exp Dermatol 27:672-674 |
| Broxton, Chynna N; He, Bixi; Bruno, Vincent M et al. (2018) A role for Candida albicans superoxide dismutase enzymes in glucose signaling. Biochem Biophys Res Commun 495:814-820 |
| Lee, Christine C; Li, Bing; Yu, Hongtao et al. (2018) A Method for SUMO Modification of Proteins in vitro. Bio Protoc 8: |
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