Abstract

Program Characteristics: This application is a revision of a renewal application requesting continuing support for a cancer biology training program at the University of Texas at Austin to provide predoctoral training in basic multidisciplinary research in tumor biology. The major goal is to train excellent scientists who will subsequently pursue successful independent research in tumor biology. Training emphasis derives from the strengths of the training faculty and will be in the areas of chemical and viral carcinogenesis, immunology, and cellular and molecular biology. Trainees will be drawn from students who have matriculated in the Department of Microbiology, the Molecular Biology Program, and the Division of Biological Sciences Graduate Programs of the Graduate School of the University of Texas at Austin. All trainees will be required to take a core series of courses in cell and molecular biology and to complete graduate level courses in immunobiology, fundamentals of tumor biology, virology, and mechanisms of carcinogenesis. Trainees will also participate in short, highly focused courses in research techniques and in various aspects of carcinogenesis and tumor biology. Past courses have included transcriptional control, RNA processing, oncogenes and signalling. Opportunities also exist for trainees to attend the NCI-sponsored tumor biology course at Keystone, Colorado.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009583-10
Application #
2894412
Study Section
Cancer Institutional Fellowship Review Committee (CT)
Program Officer
Gorelic, Lester S
Project Start
1988-04-01
Project End
2000-05-31
Budget Start
1999-07-06
Budget End
2000-05-31
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Texas Austin
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712

  Publications

Liss, Andrew S; Bose Jr, Henry R (2002) Mutational analysis of the v-Rel dimerization interface reveals a critical role for v-Rel homodimers in transformation. J Virol 76:4928-39
Kralova, Jarmila; Liss, Andrew S; Bargmann, William et al. (2002) Differential regulation of the inhibitor of apoptosis ch-IAP1 by v-rel and the proto-oncogene c-rel. J Virol 76:11960-70
Piffat, K A; Hrdlickova, R; Nehyba, J et al. (2001) The chicken RelB transcription factor has transactivation sequences and a tissue-specific expression pattern that are distinct from mammalian RelB. Mol Cell Biol Res Commun 4:266-75
Wrona, T J; Lozano, M; Binhazim, A A et al. (1998) Mutational and functional analysis of the C-terminal region of the C3H mouse mammary tumor virus superantigen. J Virol 72:4746-55
Occhino, D A; Wyckoff, E E; Henderson, D P et al. (1998) Vibrio cholerae iron transport: haem transport genes are linked to one of two sets of tonB, exbB, exbD genes. Mol Microbiol 29:1493-507
Mulvey, M; Brown, D T (1995) Involvement of the molecular chaperone BiP in maturation of Sindbis virus envelope glycoproteins. J Virol 69:1621-7
Mulvey, M; Brown, D T (1994) Formation and rearrangement of disulfide bonds during maturation of the Sindbis virus E1 glycoprotein. J Virol 68:805-12
Romach, E; Moore, J; Rummel, S et al. (1994) Influence of sex and carcinogen treatment protocol on tumor latency and frequency of K-ras mutations in N-methyl-N-nitrosourea-induced lymphomas. Carcinogenesis 15:2275-80
Croix, D A; Yeh, H Y; Sedlacek, J et al. (1993) A dominant epitope of HIV-1 protease recognized by hamster monoclonal antibodies. J Acquir Immune Defic Syndr 6:558-66
Saxena, P; Walker, J R (1992) Expression of argU, the Escherichia coli gene coding for a rare arginine tRNA. J Bacteriol 174:1956-64

Showing the most recent 10 out of 13 publications