This proposal is a competitive renewal request submitted in response to PA-16-152 for continued funding of the Signal Transduction and Cancer Postdoctoral Training Program at the Robert H. Lurie Comprehensive Cancer Center (RHLCCC) of Northwestern University.
The specific aims of the Program are: 1) to provide state of the art laboratory training to postdoctoral fellows in signal transduction and cancer, 2) to promote the recruitment of highly talented postdoctoral fellows with a special emphasis on attracting underserved minority trainees and 3) to support the career development of postdoctoral fellows in the program such that they can effectively contribute to translational cancer research. With strong Institutional support, the training program brings together a cadre of senior researchers, investigators who are new to the RHLCCC and three junior investigators, all of whom focus on aberrations in signaling pathways that contribute to the development of cancer. These preceptors are highly accomplished faculty at Northwestern University and members of the RHLCCC. A new feature of this program has been the development of a specialized curriculum in translational research that emanates from a newly established Translational Bridge Program at the RHLCCC. As described in the application, the curriculum consists of a core curriculum of coursework, seminars, symposia and journal clubs in addition to the mandatory course in Responsible Conduct of Research and training in scientific rigor and responsibility. The T32 has trained fifty postdoctoral fellows since inception of the Program in 1997; fourteen of our former trainees are in faculty positions, eighteen are senior scientists in industry and one is in a related admin position. The majority of our former trainees are engaged in cancer and signaling-related positions. We therefore request continued support for four postdoctoral fellows per year that will enable us to continue to offer focused training in signal transduction and cancer at the RHLCCC.

Public Health Relevance

This Program trains postdoctoral fellows in the field of signal transduction and cancer and prepares them for careers as independent scientists. A group of well-funded and highly qualified faculty at Northwestern University who investigate different areas of signaling and cancer have been assembled to provide guidance and mentorship to postdoctoral trainees.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA070085-23
Application #
9765165
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Lim, Susan E
Project Start
1997-05-01
Project End
2022-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
23
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Bell, Jonathan B; Eckerdt, Frank; Dhruv, Harshil D et al. (2018) Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation. Mol Cancer Res 16:32-46
Sang, Youzhou; Li, Yanxin; Song, Lina et al. (2018) TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3. Cancer Res 78:1792-1804
Pangeni, Rajendra P; Zhang, Zhou; Alvarez, Angel A et al. (2018) Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma. Epigenetics 13:432-448
Wang, Lu; Ozark, Patrick A; Smith, Edwin R et al. (2018) TET2 coactivates gene expression through demethylation of enhancers. Sci Adv 4:eaau6986
Murmann, Andrea E; Gao, Quan Q; Putzbach, William E et al. (2018) Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells. EMBO Rep 19:
Putzbach, William; Gao, Quan Q; Patel, Monal et al. (2018) DISE: A Seed-Dependent RNAi Off-Target Effect That Kills Cancer Cells. Trends Cancer 4:10-19
Ladomersky, Erik; Zhai, Lijie; Lenzen, Alicia et al. (2018) IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma. Clin Cancer Res 24:2559-2573
Gilles, Laure; Arslan, Ahmet Dirim; Marinaccio, Christian et al. (2017) Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis. J Clin Invest 127:1316-1320
Wang, Lu; Collings, Clayton K; Zhao, Zibo et al. (2017) A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism. Genes Dev 31:2056-2066
Arslan, A D; Sassano, A; Saleiro, D et al. (2017) Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma. Oncogene 36:6006-6019

Showing the most recent 10 out of 100 publications