Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA077109-04
Application #
6376646
Study Section
Subcommittee G - Education (NCI)
Project Start
1998-07-01
Project End
2003-04-30
Budget Start
2001-05-01
Budget End
2002-04-30
Support Year
4
Fiscal Year
2001
Total Cost
$95,083
Indirect Cost
Name
University of California San Diego
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Eckert, Mark A; Santiago-Medina, Miguel; Lwin, Thinzar M et al. (2017) ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions. J Cell Sci 130:2036-2048
Wei, Spencer C; Yang, Jing (2016) Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial-Mesenchymal Transition. Trends Cell Biol 26:111-120
Deryugina, Elena I; Quigley, James P (2015) Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature. Matrix Biol 44-46:94-112
Wei, Spencer C; Fattet, Laurent; Tsai, Jeff H et al. (2015) Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol 17:678-88
Chen, Meifan; Gutierrez, Gustavo J; Ronai, Ze'ev A (2012) The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress. PLoS One 7:e35520
Botkjaer, Kenneth A; Deryugina, Elena I; Dupont, Daniel M et al. (2012) Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism. Mol Cancer Res 10:1532-43
Bekes, Erin M; Deryugina, Elena I; Kupriyanova, Tatyana A et al. (2011) Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells. Neoplasia 13:806-21
Timmer, John C; Salvesen, Guy S (2011) N-terminomics: a high-content screen for protease substrates and their cleavage sites. Methods Mol Biol 753:243-55
Eckert, Mark A; Lwin, Thinzar M; Chang, Andrew T et al. (2011) Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell 19:372-86
Chen, Meifan; Gutierrez, Gustavo J; Ronai, Ze'ev A (2011) Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. Proc Natl Acad Sci U S A 108:9119-24

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