The Pharmacology Department at the Robert Wood Johnson Medical School (RWJMS) in collaboration with the faculty at the Ernest Mario School of Pharmacy at Rutgers University (EMSOP, RU) and the Cancer Institute of New Jersey (CINJ), are requesting funds to support a training program in cancer pharmacology for postdoctoral and predoctoral fellows. The collaborative program brings together faculty from the three participating institutions with a common interest in cancer pharmacology. The major strengths of the program include the top quality of the faculty, existing research collaborations between the faculty and the opportunity for the trainees for research in both basic as well as applied cancer pharmacology. Additionally, the trainees will be able to: a) serve as interns in the pharmaceutical industry that are located in the immediate vicinity of the campus around Piscataway and New Brunswick, NJ to become familiar with various aspects of pre clinical drug development and cancer pharmacology in the industrial setting and b) observe first hand the role cancer pharmacology plays in clinical oncology practice. The training grant will be a unique opportunity to attract talented candidates and train them to become future research scientists in cancer pharmacology. The predoctoral trainees will be enrolled in the Cellular and Molecular Pharmacology Graduate Program administered by the Pharmacology Department at RWJMS that involves both course work and laboratory research. Postdoctoral trainees, in addition to basic laboratory research in cancer pharmacology with one of the faculty, will be required to take two of the elective courses related to cancer and cancer pharmacology offered in the Department of Pharmacology. The faculty mentors of this training program from the three institutions have a broad range of research interests that span cell cycle control, basic mechanisms of tumorigenesis, understanding mechanisms of drug action and resistance, cancer gene therapy and non-invasive in vivo imaging, with a shared interest in cancer pharmacology ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA108455-04
Application #
7498567
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
2005-09-29
Project End
2010-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
4
Fiscal Year
2008
Total Cost
$276,333
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Pharmacology
Type
Schools of Medicine
DUNS #
617022384
City
Piscataway
State
NJ
Country
United States
Zip Code
08854
Barboza, Nora M; Medina, Daniel J; Budak-Alpdogan, Tulin et al. (2012) Plitidepsin (Aplidin) is a potent inhibitor of diffuse large cell and Burkitt lymphoma and is synergistic with rituximab. Cancer Biol Ther 13:114-22
Ju, Jihyeung; Picinich, Sonia C; Yang, Zhihong et al. (2010) Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis 31:533-42
Tsai, Yuan-Chin; Qi, Haiyan; Lin, Chao-Po et al. (2009) A G-quadruplex stabilizer induces M-phase cell cycle arrest. J Biol Chem 284:22535-43
Pilch, Daniel S; Barbieri, Christopher M; Rzuczek, Suzanne G et al. (2008) Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds. Biochimie 90:1233-49
Lin, Siang-Yo; Yang, Jun; Everett, Allen D et al. (2008) The isolation of novel mesenchymal stromal cell chemotactic factors from the conditioned medium of tumor cells. Exp Cell Res 314:3107-17
Barbieri, Christopher M; Srinivasan, Annankoil R; Rzuczek, Suzanne G et al. (2007) Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA. Nucleic Acids Res 35:3272-86
Qi, Haiyan; Lin, Chao-Po; Fu, Xuan et al. (2006) G-quadruplexes induce apoptosis in tumor cells. Cancer Res 66:11808-16