Abstract

This is a new application for a Cancer Biology Training Program at Indiana University School of Medicine which is located on the Indiana University Purdue University at Indianapolis campus. The goal of the Program is to produce postdoctoral and predoctoral trainees who have experienced an interdisciplinary environment of interacting basic scientists and clinicians committed to cancer research. Strengths of the Program include the quality of the preceptors and environment and the diversity of cancer research. The twenty-seven preceptors are members of the Indiana University Cancer Center and the Indiana University Graduate School. They have primary or secondary appointments in the Departments of Biochemistry and Molecular Biology, Cellular and Integrative Physiology, Medical and Molecular Genetics, Microbiology and Immunology, and Pharmacology and Toxicology. Several also have primary appointments in Medicine, Obstetrics and Gynecology, Pediatrics, Surgery, or Urology. The preceptors are highly interactive, collaborating in both the research and teaching arenas. Support is requested for 6 postdoctoral and 2 predoctoral trainees. In addition to their research, postdoctoral and predoctoral trainees will participate in two weekly cancer seminar series: a basic science series and Grand Rounds. For one year each, the trainees will attend and present their research in a monthly meeting of the Regulation of Cell Growth Program and the Experimental Therapeutics Program of the Indiana University Cancer Center. Also, the trainees will present their research at the Indiana University Cancer Center Annual Cancer Research Day. All trainees will take a course in scientific ethics. Postdoctoral trainees will be Ph.D.s. recruited into individual laboratories or M.D.s participating in the clinical fellowship programs. Requirement of didactic coursework will be tailored to the particular background of the postdoctoral fellow. Predoctoral trainees will fulfill the requirements of their individual departments and complete a Cancer Biology Minor or equivalent coursework.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA111198-04
Application #
7447328
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
2005-04-01
Project End
2010-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
4
Fiscal Year
2008
Total Cost
$369,390
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Zeng, Yi; Broxmeyer, Hal E; Staser, Karl et al. (2015) Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation. Stem Cells 33:1630-41
Burnett, Riesa M; Craven, Kelly E; Krishnamurthy, Purna et al. (2015) Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells. Oncotarget 6:12682-96
Glosson-Byers, Nicole L; Sehra, Sarita; Stritesky, Gretta L et al. (2014) Th17 cells demonstrate stable cytokine production in a proallergic environment. J Immunol 193:2631-40
Pardo, Ivanesa; Lillemoe, Heather A; Blosser, Rachel J et al. (2014) Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank. Breast Cancer Res 16:R26
Radovich, Milan; Clare, Susan E; Atale, Rutuja et al. (2014) Characterizing the heterogeneity of triple-negative breast cancers using microdissected normal ductal epithelium and RNA-sequencing. Breast Cancer Res Treat 143:57-68
Pham, Duy; Yu, Qing; Walline, Crystal C et al. (2013) Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. J Immunol 191:902-11
Staser, Karl; Park, Su-Jung; Rhodes, Steven D et al. (2013) Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk. J Clin Invest 123:329-34
Staser, Karl; Shew, Matthew A; Michels, Elizabeth G et al. (2013) A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells. Exp Hematol 41:56-66.e2
Staser, Karl; Yang, Feng-Chun; Clapp, D Wade (2012) Pathogenesis of plexiform neurofibroma: tumor-stromal/hematopoietic interactions in tumor progression. Annu Rev Pathol 7:469-95
Aregbe, Abdulateef O; Sherer, Eric A; Egorin, Merrill J et al. (2012) Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors. Cancer Chemother Pharmacol 70:201-5

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