? ? This application is in response to RFA-DA-06-008 entitled Training in Translational Research in Neurobiology of Disease (T32). The overall goal of the proposed Therapeutic Strategies for Neurodegeneration Training Program is to prepare promising predoctoral scholars (graduate students), postdoctoral scholars and clinical scholars for successful careers in translational neuroscience aimed at the discovery and development of disease-modifying pharmacological and genetic therapies for devastating neurodegenerative disorders or diseases such as spinal cord injury (SCI), traumatic brain injury (TBI), stroke, and Parkinson's Disease (PD). We will provide broad-based training in modern research concepts regarding the pathophysiology of these and other neurodegenerative disorders and potential disease modifying molecular targets that can drive the discovery of pharmacological and gene therapeutic strategies by which the devastating effects of these disorders can be ameliorated. These strategies will include both """"""""neuroprotective"""""""" and """"""""neurorestorative"""""""" approaches. Funding is requested for 5 Predoctoral Scholars each year for 5 years. Beginning in year 2, funds are requested for 1 Postdoctoral Scholar and 1 Clinical Trainee. In the case of the latter, the purpose is to provide a 1 year fellowship for a late stage neurology or neurosurgery resident, a clinical fellow, or a young Assistant Professor to spend a year cross-training in a basic research laboratory. Fourteen basic science and 5 clinical faculty from two basic science departments (Anatomy and Neurobiology and Physiology), two clinical departments (Neurology and Neurosurgery) and three centers (Spinal Cord & Brain Injury Research Center, Morris K. Udall Parkinson's Disease Research Center, and the Sanders-Brown Center on Aging) will participate in this Training Program. The training program for all of the trainees involves a strong emphasis on translationally-focused therapeutic discovery basic research. For the Predoctoral and Postdoctoral Scholars, each will be expected to complete a multi faceted Clinical Tutorial specifically designed to be relevant to the disease focus of their research. All of the trainees will have the opportunity to participate in a rich offering of didactic course work, seminars, annual translationally-oriented research symposia and research externships and training courses. Recruitment of women and minorities will be emphasized. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA022738-02
Application #
7292822
Study Section
Special Emphasis Panel (ZDA1-KXN-G (08))
Program Officer
Babecki, Beth
Project Start
2006-09-26
Project End
2011-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
2
Fiscal Year
2007
Total Cost
$268,783
Indirect Cost
Name
University of Kentucky
Department
Neurology
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Miller, Darren M; Singh, Indrapal N; Wang, Juan A et al. (2015) Nrf2-ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in mice. Exp Neurol 264:103-10
Miller, Darren M; Wang, Juan A; Buchanan, Ashley K et al. (2014) Temporal and spatial dynamics of nrf2-antioxidant response elements mediated gene targets in cortex and hippocampus after controlled cortical impact traumatic brain injury in mice. J Neurotrauma 31:1194-201
Fuqua, Joshua L; Littrell, Ofelia M; Lundblad, Martin et al. (2014) Dynamic changes in dopamine neuron function after DNSP-11 treatment: effects in vivo and increased ERK 1/2 phosphorylation in vitro. Peptides 54:1-8
Miller, Darren M; Singh, Indrapal N; Wang, Juan A et al. (2013) Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo. Free Radic Biol Med 57:1-9
Littrell, Ofelia M; Granholm, Ann-Charlotte; Gerhardt, Greg A et al. (2013) Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF. Pharmacol Biochem Behav 104:10-9
Schoch, Kathleen M; von Reyn, Catherine R; Bian, Jifeng et al. (2013) Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse. J Neurochem 125:909-20
Littrell, O M; Fuqua, J L; Richardson, A D et al. (2013) A synthetic five amino acid propeptide increases dopamine neuron differentiation and neurochemical function. Neuropeptides 47:43-9
Bains, Mona; Hall, Edward D (2012) Antioxidant therapies in traumatic brain and spinal cord injury. Biochim Biophys Acta 1822:675-84
Kang, Hae-Eun; Weng, Chu Chun; Saijo, Eri et al. (2012) Characterization of conformation-dependent prion protein epitopes. J Biol Chem 287:37219-32
Hall, Edward D; Wang, Juan A; Miller, Darren M (2012) Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury. Exp Neurol 238:176-82

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