This application is a competing renewal application for years 37-41 for this Training Grant in Diabetes and Endocrinology. It was the first, and remains the longest-running, T-32 grant at the University of Pittsburgh School of Medicine. The goals of the application are: A. To attract outstanding MD and PhD postdoctoral trainees with authentic academic interests and potential B. To pair them with similarly outstanding research training faculty to serve as mentors C. To provide a venue for outstanding training and mentoring in diabetes, obesity, bone and mineral, osteoporosis, endocrine epidemiology, as well as basic cellular and molecular endocrinology research D. To eliminate the barriers between clinical, basic and translational research in Endocrinology E. To support the trainee's and mentor's needs in providing this outstanding training F. To provide a supportive and highly enriching didactic environment in which to receive this training G. To help the trainees transition to junior faculty positions H. To adequately protect MD trainees from clinical responsibilities while receiving research training I. To provide opportunities for research training to all members of underrepresented ethnic, disadvantaged and disabled groups J. To provide formal, documented instruction in research integrity, responsible conduct of research as well as all other areas of research conduct and compliance In the last round of funding, the program has shown a strong record of meeting all of these goals, with 58- 74% of graduates in the past 10 years now serving in academic positions, depending on how rigorously """"""""academic"""""""" is defined

Public Health Relevance

This Training Grant helps to replenish the supply of academic specialists, both MD and PhD, in topical areas of national health priorities, such as diabetes, obesity, osteoporosis, and women's health. It supports a high quality program, and its quality is continuing to further improve with each year, by every objective measure. It has been successful in training, excellent candidates, with half to three quarters of trainees in the past 10 years remaining in academia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
3T32DK007052-41S1
Application #
8915340
Study Section
Special Emphasis Panel (ZDK1-GRB-W (J3))
Program Officer
Castle, Arthur
Project Start
1975-07-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
41
Fiscal Year
2014
Total Cost
$72,344
Indirect Cost
$5,130
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Kim, Joon Young; Tfayli, Hala; Michaliszyn, Sara F et al. (2018) Impaired Lipolysis, Diminished Fat Oxidation, and Metabolic Inflexibility in Obese Girls With Polycystic Ovary Syndrome. J Clin Endocrinol Metab 103:546-554
Frahm, Krystle A; Waldman, Jacob K; Luthra, Soumya et al. (2018) A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells. Mol Cell Endocrinol 471:42-50
Corbit, Kevin C; Camporez, João Paulo G; Edmunds, Lia R et al. (2018) Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes 67:208-221
Xiong, Jianhua; Kawagishi, Hiroyuki; Yan, Ye et al. (2018) A Metabolic Basis for Endothelial-to-Mesenchymal Transition. Mol Cell 69:689-698.e7
Kim, Joon Young; Nasr, Alexis; Tfayli, Hala et al. (2017) Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity, and Impaired ?-Cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth With Impaired Glucose Tolerance. Diabetes 66:3085-3090
Howlett, Evan H; Jensen, Nicholas; Belmonte, Frances et al. (2017) LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease. Hum Mol Genet 26:4340-4351
Costa, Diana K; Huckestein, Brydie R; Edmunds, Lia R et al. (2016) Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice. Am J Physiol Endocrinol Metab 311:E105-16
Wang, Huabo; Lu, Jie; Edmunds, Lia R et al. (2016) Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma. J Biol Chem 291:26241-26251
Bannwarth, Sylvie; Berg-Alonso, Laetitia; Augé, Gaëlle et al. (2016) Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice. Mitochondrion 30:126-37
Belmonte, Frances R; Martin, James L; Frescura, Kristin et al. (2016) Digital PCR methods improve detection sensitivity and measurement precision of low abundance mtDNA deletions. Sci Rep 6:25186

Showing the most recent 10 out of 59 publications