Abstract

This research is in progress. This year we carried out extensive behavioral testing,such as the Morris water maze,radial arm maze and fear conditioning in mice housed under exercise and enrichment conditions. We found that exercsie is the main stimulus of neurogenesis and not enrichment. Our manuscript describing these findings is in press with the journal 'learning and Meory' For the viral vector work we have injected vectors in to the dentate gyrus of the hippocampus of young adult C57Bl/6 mice. We are analyzing histological and physiological data.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000328-04
Application #
8335820
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2011
Total Cost
$392,854
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Cooper, C'iana; Moon, Hyo Youl; van Praag, Henriette (2018) On the Run for Hippocampal Plasticity. Cold Spring Harb Perspect Med 8:
Mohammad, H; Marchisella, F; Ortega-Martinez, S et al. (2017) JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche. Mol Psychiatry :
Jongbloets, Bart C; Lemstra, Suzanne; Schellino, Roberta et al. (2017) Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nat Commun 8:14666
Moon, Hyo Youl; Becke, Andreas; Berron, David et al. (2016) Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function. Cell Metab 24:332-40
Vivar, Carmen; Peterson, Benjamin D; van Praag, Henriette (2016) Running rewires the neuronal network of adult-born dentate granule cells. Neuroimage 131:29-41
Duzel, Emrah; van Praag, Henriette; Sendtner, Michael (2016) Can physical exercise in old age improve memory and hippocampal function? Brain 139:662-73
Tweedie, David; Fukui, Koji; Li, Yazhou et al. (2016) Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms. PLoS One 11:e0156493
Guerrieri, Davide; van Praag, Henriette (2015) Exercise-mimetic AICAR transiently benefits brain function. Oncotarget 6:18293-313
Stringer, T P; Guerrieri, D; Vivar, C et al. (2015) Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice. Transl Psychiatry 5:e493
Moon, Hyo Youl; van Praag, Henriette (2014) Muscle over mind. Cell Metab 20:560-2

Showing the most recent 10 out of 33 publications