application) A multidisciplinary group of senior investigators at Columbia, with a common interest in the mechanisms that protect the bowel from microbial infection, have designed a GI Infection and Inflammation training program and request support. Funds are requested for 2 pre-doctoral fellows in the year 1, 3 pre-doctoral fellows in year 2 and 4 pre-doctoral fellows in years 3-5. Historically, at Columbia, basic research on infection was centered in the Dept. of Microbiology. Study of pathogenesis, however, has increasingly involved the study of cell biology, because of the ability of invading organisms to exploit host cell machinery to carry out their nefarious life cycles. Similarly, microbiologists are now just as concerned about cell biology as members of the department that bears that name. It is thus both realistic and important to expose trainees broadly to many disciplines. Bacterial and viral pathogenesis provides a great multidisciplinary training opportunity of which we now propose to take full advantage. In addition, the best pre-doctoral applicants are interested in the mechanisms of disease and want it included in their predoctoral training. Accordingly, 18 faculty from 4 basic and 3 clinical science departments have joined together to develop a thematic, interdepartmental pre-doctoral training program in GI infection and inflammation. Participating faculty include: Q. Al-Awqati (differentiation & membrane trafficking of gut epithelium); J. Bulinski (microtubule function in intracellular transport); M. Field (ion transport across intestinal epithelial membranes); M. Gershon (development & function of the enteric nervous system); A. Gershon (Herpes virus and HIV infection); S. Goff (retrovirus infection & replication); G. Gundersen (microtubule control of membrane trafficking); R. Kessin (mechanisms of phagocytosis); R. Liem (cytoskeleton of the enteric nervous system); J. Luan (HIV-1 replication & pathogenesis); A. Mitchell (infection by the fungus, Candida albicans); L. Pon (actin cytoskeletal control of membrane trafficking & enterobacterial infection); A. Prince (bacteria-host interactions); V. Racaniello (enterovirus pathogenesis); H. Shuman (pathogenesis of enterobacteria); S. Silverstein (membrane transport & leukocytes); and H. Worman (inflammatory bowel, and hepatobiliary diseases and hepatitis C). The multidisciplinary nature of this program is congruent with an evolution of graduate education at Columbia University. It also provides, for the first time in years, an institutional focus on research and research training in GI disease. The inception of this program has already led to the development of new graduate courses, expansion of existing courses and establishment of new collaborations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
1T32DK007786-01A1
Application #
6215943
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2001-02-01
Project End
2006-01-31
Budget Start
2001-02-01
Budget End
2002-01-31
Support Year
1
Fiscal Year
2001
Total Cost
$77,171
Indirect Cost
Name
Columbia University (N.Y.)
Department
Pathology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Nicol, Lindsey E; O'Brien, Timothy D; Dumesic, Daniel A et al. (2014) Abnormal infant islet morphology precedes insulin resistance in PCOS-like monkeys. PLoS One 9:e106527
Abbott, David H; Nicol, Lindsey E; Levine, Jon E et al. (2013) Nonhuman primate models of polycystic ovary syndrome. Mol Cell Endocrinol 373:21-8
Nobile, Clarissa J; Mitchell, Aaron P (2009) Large-scale gene disruption using the UAU1 cassette. Methods Mol Biol 499:175-94
Boldogh, Istvan R; Fehrenbacher, Kammy L; Yang, Hyeong-Cheol et al. (2005) Mitochondrial movement and inheritance in budding yeast. Gene 354:28-36
Richard, Mathias L; Nobile, Clarissa J; Bruno, Vincent M et al. (2005) Candida albicans biofilm-defective mutants. Eukaryot Cell 4:1493-502
Fehrenbacher, Kammy L; Boldogh, Istvan R; Pon, Liza A (2005) A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast. Mol Biol Cell 16:5094-102
Fehrenbacher, Kammy L; Yang, Hyeong-Cheol; Gay, Anna Card et al. (2004) Live cell imaging of mitochondrial movement along actin cables in budding yeast. Curr Biol 14:1996-2004
Nobile, Clarissa J; Bruno, Vincent M; Richard, Mathias L et al. (2003) Genetic control of chlamydospore formation in Candida albicans. Microbiology 149:3629-37