This application requests funding for a new Training Program in gastroenterology at Case Western Reserve University (CWRU). The long-term goal of the program is to train qualified individuals with a M.D., M.D./Ph.D., or Ph.D. degree committed to a research career in the broad field of gastroenterology. The program will educate such individuals in a comprehensive fashion so that, upon completing the program, they will be able to function as independent investigators and successfully compete for funding at the national level. The foundation of the proposed program is based on the strategic planning and consolidated efforts of the Division of Gastroenterology, that has achieved a reputation of excellence based on superior clinical and basic research, ample funding from the NIH, and a combined research space in excess of 40,000 square feet. An essential aspect of the program is that research will cut across Divisional and Departmental lines as all enlisted mentors have a tradition of highly productive collaborations and have trained a large number of investigators in an effective interdisciplinary manner. Twenty-eight core preceptors and collaborating faculty from five Departments, representing a wide range of scientific interest and technical expertise, will offer a diversity of training opportunities that will be tailored to the scientific background and career goals of each trainee. The research activities covered by the preceptors and collaborating faculty will include the broad topics of immunology, molecular biology, epidemiology, outcome studies, social medicine, pathology, gastrointestinal cancer, and advanced endoscopy. In addition to the resources available in the laboratories of individual mentors, the trainees will take advantage of the rich scientific environment of CWRU that has a large number of training grants as demonstration of institutional commitment to the development of future generations of academicians. This application seeks 2 post-doctoral positions in year 1, and 2 new trainee positions in each of the subsequent years. Each successful applicant will be trained for a minimum period of two years by the institutional grant. After that, 1 or 2 subsequent years may be offered to selected trainees, to be supported by other individual or institutional training grants, or grants to which the trainee will apply during his/her official training period.
| Goh, George Bb; Issa, Danny; Lopez, Rocio et al. (2016) The development of a non-invasive model to predict the presence of non-alcoholic steatohepatitis in patients with non-alcoholic fatty liver disease. J Gastroenterol Hepatol 31:995-1000 |
| Goh, George Boon-Bee; Pagadala, Mangesh R; Dasarathy, Jaividhya et al. (2015) Age impacts ability of aspartate-alanine aminotransferase ratio to predict advanced fibrosis in nonalcoholic Fatty liver disease. Dig Dis Sci 60:1825-31 |
| Goh, George B; Pagadala, Mangesh R; Dasarathy, Jaividhya et al. (2015) Renin-angiotensin system and fibrosis in non-alcoholic fatty liver disease. Liver Int 35:979-85 |
| Goh, George Boon-Bee; Pagadala, Mangesh R; Dasarathy, Jaividhya et al. (2015) Clinical spectrum of non-alcoholic fatty liver disease in diabetic and non-diabetic patients. BBA Clin 3:141-5 |
| Wang, Ming-Hsi; Fiocchi, Claudio; Zhu, Xiaofeng et al. (2014) Gene-gene and gene-environment interactions in ulcerative colitis. Hum Genet 133:547-58 |
| Wakim-Fleming, Jamile; Pagadala, Mangesh R; McCullough, Arthur J et al. (2014) Prevalence of celiac disease in cirrhosis and outcome of cirrhosis on a gluten free diet: a prospective study. J Hepatol 61:558-63 |
| Haus, Jacob M; Solomon, Thomas P J; Kelly, Karen R et al. (2013) Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 98:E1181-8 |
| Wakim-Fleming, Jamile'; Pagadala, Mangesh R; Lemyre, Martin S et al. (2013) Diagnosis of celiac disease in adults based on serology test results, without small-bowel biopsy. Clin Gastroenterol Hepatol 11:511-6 |
| Sourianarayanane, A; Pagadala, M R; Kirwan, J P (2013) Management of non-alcoholic fatty liver disease. Minerva Gastroenterol Dietol 59:69-87 |
| Cummings, Linda C; Shah, Ninad; Maimone, Santo et al. (2013) Barrett's esophagus and the risk of obstructive sleep apnea: a case-control study. BMC Gastroenterol 13:82 |
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