? The goal of our training program is to prepare clinical investigators and basic medical scientists for productive, independent investigative careers in the area of renal disease. This would require a minimum of 2 years exposure to intensive laboratory experience or clinical research working closely with one of the program faculty. Candidates must be MDs who have completed an approved Internal Medicine Residency or PhDs in a biomedical field. Many of the fundamental advances in the field of Nephrology are as a result of laboratory-based research being increasingly transferred to clinical practice. Accordingly, our training program will emphasize both laboratory-based and clinical/translation research in the physiology and pathophysiology of the kidney. The quality and the dedicated effort of the program faculty are primary factors assuring success of the research training. Consequently, the program faculty is limited to investigators with active, on going funded laboratory-based or clinical/translation research programs with documented training records who can provide hands-on research experience for trainees. The program faculty represents a closely-knit interacting multidisciplinary faculty from the departments of Medicine, Pathology, Pharmacology and Toxicology, and Biochemistry, Geriatrics and Physiology and includes 6 MDs, 6 PhDs, 2 MD/PhDs, and 2 MD/MPHs. While each individual member conducts his specific-funded program in his own right, most of the program faculty interact with each other and meet on a regular basis to discuss respective research efforts as well as explore collaborative projects. Such inter-laboratory cooperation is very useful for expanding the outlook of research fellows who become familiar with a wider variety of methods and multidisciplinary strategic approaches to the solution of scientific problems. The trainees have the option of obtaining an MPH degree or are expected to participate in regularly scheduled activities sponsored by the School of Public Health and other departments targeted toward the scientific method and statistical analysis; attend conferences sponsored by Medicine, Physiology and Biochemistry; and attend the weekly research conference held as a part of Program Project. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK061921-02
Application #
7278792
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
Project Start
2006-09-01
Project End
2011-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
2
Fiscal Year
2007
Total Cost
$125,770
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Farris, R A; Price, E T (2017) Reverse Translational Study of Fenofibrate's Observed Effects in Diabetes-Associated Retinopathy. Clin Transl Sci 10:110-116
Shrum, S; MacMillan-Crow, L A; Parajuli, N (2016) Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation. J Kidney 2:
Singh, P; Parajuli, N; Mayeux, P R et al. (2016) Renal Mitochondrial Lipid Peroxidation during Sepsis. J Kidney 2:
Chandrika, Bhavya B; Yang, Cheng; Ou, Yang et al. (2015) Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury. PLoS One 10:e0140025
Patil, Naeem K; Parajuli, Nirmala; MacMillan-Crow, Lee Ann et al. (2014) Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury. Am J Physiol Renal Physiol 306:F734-43
Singh, Mandeep; Odeniyi, Dolapo T; Apostolov, Eugene O et al. (2013) Protective effect of zinc-N-acetylcysteine on the rat kidney during cold storage. Am J Physiol Renal Physiol 305:F1022-30
Hodeify, Rawad; Megyesi, Judit; Tarcsafalvi, Adel et al. (2013) Gender differences control the susceptibility to ER stress-induced acute kidney injury. Am J Physiol Renal Physiol 304:F875-82
Li, Shenyang; Mariappan, Nithya; Megyesi, Judit et al. (2013) Proximal tubule PPAR? attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction. Am J Physiol Renal Physiol 305:F618-27
Parajuli, Nirmala; MacMillan-Crow, Lee Ann (2013) Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis? Am J Physiol Renal Physiol 304:F257-67
Sun, Jinchun; Shannon, Melissa; Ando, Yosuke et al. (2012) Serum metabolomic profiles from patients with acute kidney injury: a pilot study. J Chromatogr B Analyt Technol Biomed Life Sci 893-894:107-13

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