The burden of diabetes and its complications underscores the continued need to train the next generation of well-qualified scientists to develop new ideas and novel therapies for the treatment, prevention and cure of diabetes. The primary goal of this training grant is to prepare PhD basic scientists for careers in diabetes research. The training includes multidisciplinary and comprehensive learning experiences, as well as the mentorship and laboratory research experiences required to develop a deep understanding of the molecular aspects of diabetes. This training program is embedded within the rich research environment of the University of Michigan, which includes a highly collegial, interdisciplinary diabetes research community with outstanding core resources to support biomedical research. The training program builds on the unique expertise of preceptors, which fall into six major interest groups ? islet biology, autoimmune diabetes, adipocyte biology, hypothalamic regulation of metabolism, mechanisms of insulin resistance and metabolic control (liver, adipocyte and muscle groups), and diabetes complications. The program includes training that occurs within individual research laboratories, but is supplemented by a core curriculum - with lectures on molecular pathogenesis of diabetes, cell and developmental biology, responsible conduct of research, and research methodologies. In addition, the trainees attend a variety of interdisciplinary seminars, activities in grant writing, career strategy workshops, and meet with visiting speakers. The Director mentors the trainees in individual and small group sessions. This training is designed to provide the necessary tools for transition to independence. This program includes 27 mentors in a highly collaborative environment, all with stable extramural funding. The mentors are diverse in their area of specialty, with appointments in Schools of Kinesiology, Literature Sciences & Arts, and many departments and divisions within the School of Medicine. This program will provide a significant complement for the missions of the Michigan Diabetes Research Center and the Nutrition and Obesity Research Center, which support research infrastructure but provide no support for postdoctoral trainees. This training program will be overseen by an executive committee comprising the Principal Investigator and co-director, plus three members all of whom are senior investigators with strong mentoring track records.

Public Health Relevance

Our program provides basic scientists with a deep understanding of the molecular aspects of diabetes through strong laboratory-based research experiences, excellent mentorship, and an academic environment with a focus on multidisciplinary and comprehensive diabetes research. Training is a combination of immersion in specific research projects under the direction of experienced and accomplished senior researchers, formal education, and participation in a variety of other research- related educational activities. This training program fills a critical need to increase the number of future leaders in diabetes research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK101357-06
Application #
9699661
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
2014-09-01
Project End
2024-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Muir, Lindsey A; Kiridena, Samadhi; Griffin, Cameron et al. (2018) Frontline Science: Rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages. J Leukoc Biol 103:615-628
Hinder, Lucy M; Murdock, Benjamin J; Park, Meeyoung et al. (2018) Transcriptional networks of progressive diabetic peripheral neuropathy in the db/db mouse model of type 2 diabetes: An inflammatory story. Exp Neurol 305:33-43
Peck, Bailey C E; Seeley, Randy J (2018) How does 'metabolic surgery' work its magic? New evidence for gut microbiota. Curr Opin Endocrinol Diabetes Obes 25:81-86
Adams, Jessica M; Pei, Hongjuan; Sandoval, Darleen A et al. (2018) Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons. Diabetes 67:1538-1548
Allison, Margaret B; Pan, Warren; MacKenzie, Alexander et al. (2018) Defining the Transcriptional Targets of Leptin Reveals a Role for Atf3 in Leptin Action. Diabetes 67:1093-1104
Rumora, Amy E; Lentz, Stephen I; Hinder, Lucy M et al. (2018) Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons. FASEB J 32:195-207
Baker, Nicki A; Muir, Lindsey A; Washabaugh, Alexandra R et al. (2017) Diabetes-Specific Regulation of Adipocyte Metabolism by the Adipose Tissue Extracellular Matrix. J Clin Endocrinol Metab 102:1032-1043
Muir, Lindsey A; Baker, Nicki A; Washabaugh, Alexandra R et al. (2017) Adipocyte hypertrophy-hyperplasia balance contributes to weight loss after bariatric surgery. Adipocyte 6:134-140
Baker, Nicki A; Muir, Lindsey A; Lumeng, Carey N et al. (2017) Differentiation and Metabolic Interrogation of Human Adipocytes. Methods Mol Biol 1566:61-76
Hinder, Lucy M; Park, Meeyoung; Rumora, Amy E et al. (2017) Comparative RNA-Seq transcriptome analyses reveal distinct metabolic pathways in diabetic nerve and kidney disease. J Cell Mol Med 21:2140-2152

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