The rapidly growing field of molecular imaging seeks to develop strategies for non-invasively imaging specific gene and protein targets with the goal of better understanding disease initiation and progression in vivo and accelerating the translation of basic knowledge in the biological sciences into new diagnostic and therapeutic approaches in the clinic. This is a highly interdisciplinary research field, involving scientists from the biological, engineering, physical and medical sciences. Recently, many imaging, pharmaceutical and biotechnology companies have set up molecular imaging programs. The most successful programs, whether in academia or industry, will be those in which the diverse fields listed above are well integrated, and which are led by multidisciplinary scientists that are trained in sufficient depth and breadth to generate new ideas and direct the execution of those ideas. The goal of our predoctoral training program is to train the next generation of leaders in the molecular imaging field for both academia and industry. This training program is based in biomedical engineering, a discipline that seeks to seamlessly integrate engineering, biology and medicine. It is a natural home for the imaging science that is the foundation for molecular imaging research. We propose to support six predoctoral students per year with a carefully constructed curriculum that will provide them with fundamental knowledge in engineering, cell & molecular biology, physiology, instrumentation, synthetic chemistry, and mathematics. A course in molecular imaging will take these fundamentals and show students how to apply them to particular biologic questions. Trainees can select from 16 faculty mentors that span the breadth of molecular imaging research topics. In addition, trainees can take 3- month internships to gain industrial experience, participate in a monthly molecular imaging journal club, and attend an international molecular imaging conference to see at first-hand the latest developments in the field and form connections with other scientists working on similar research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
1T32EB003827-01
Application #
6801244
Study Section
Special Emphasis Panel (ZEB1-OSR-B (M1))
Program Officer
Temple-Oconnor, Meredith D
Project Start
2004-07-01
Project End
2009-04-30
Budget Start
2004-07-01
Budget End
2005-04-30
Support Year
1
Fiscal Year
2004
Total Cost
$187,964
Indirect Cost
Name
University of California Davis
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Mitra, Debika; Fatakdawala, Hussain; Nguyen-Truong, Michael et al. (2017) Detection of Pentosidine Cross-Links in Cell-Secreted Decellularized Matrices Using Time Resolved Fluorescence Spectroscopy. ACS Biomater Sci Eng 3:1944-1954
Shapiro, Galina; Wong, Andrew W; Bez, Maxim et al. (2016) Multiparameter evaluation of in vivo gene delivery using ultrasound-guided, microbubble-enhanced sonoporation. J Control Release 223:157-164
Gorpas, Dimitris; Fatakdawala, Hussain; Bec, Julien et al. (2015) Fluorescence lifetime imaging and intravascular ultrasound: co-registration study using ex vivo human coronaries. IEEE Trans Med Imaging 34:156-66
Liu, Yu; Fite, Brett Z; Mahakian, Lisa M et al. (2015) Concurrent Visualization of Acoustic Radiation Force Displacement and Shear Wave Propagation with 7T MRI. PLoS One 10:e0139667
Fatakdawala, Hussain; Gorpas, Dimitris; Bishop, John W et al. (2015) Fluorescence Lifetime Imaging Combined with Conventional Intravascular Ultrasound for Enhanced Assessment of Atherosclerotic Plaques: an Ex Vivo Study in Human Coronary Arteries. J Cardiovasc Transl Res 8:253-63
Qin, Shengping; Fite, Brett Z; Gagnon, M Karen J et al. (2014) A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics. Ann Biomed Eng 42:280-98
Zhou, Qing; Kwa, Timothy; Gao, Yandong et al. (2014) On-chip regeneration of aptasensors for monitoring cell secretion. Lab Chip 14:276-9
Paoli, Eric E; Ingham, Elizabeth S; Zhang, Hua et al. (2014) Accumulation, internalization and therapeutic efficacy of neuropilin-1-targeted liposomes. J Control Release 178:108-17
Freedenberg, Melissa I; Badawi, Ramsey D; Tarantal, Alice F et al. (2014) Performance and limitations of positron emission tomography (PET) scanners for imaging very low activity sources. Phys Med 30:104-10
Ma, Dinglong; Bec, Julien; Yankelevich, Diego R et al. (2014) Rotational multispectral fluorescence lifetime imaging and intravascular ultrasound: bimodal system for intravascular applications. J Biomed Opt 19:066004

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