EXCEEDTHE SPACEPROVIDED. The goal of this research training program in Developmental Biology is to produce highly qualified scientists committed to careers in biological and biomedical research related to Developmental Biology, includingbasic developmental mechanisms, developmental pathways, morphogenesis, cancer, and human genetic disease that cause developmental defects. These scientists must now be well versed in many disciplines, including molecular biology, classical and molecular genetics, biochemistry, developmental biology, cell biology, and soon functional genomics. Our proposed training program provides trainees with a thorough foundation in all these areas through coursework and laboratory research experience. In addition, trainees have a wealth of opportunities to attend seminars and journal clubs in the Texas Medical Center. Funds are requested for 8 predoctoral trainees selected competitively on the basis of past performance (academic record, test scores, laboratory experience) and on the basis of motivation and enthusiasm for research (recommendations and interviews). The Program in Developmental Biology (DB Program) has been recently established and has tripled in size since its inception 7 years ago. Selected graduate students can now join laboratories of 31 participating faculty members of the DB Program throughout the Texas Medical Center. This program is one of the largest in the nation and because of its presence in the Texas Medical Center provides many unique biomedical training opportunities in Developmental Biology. The DB Training Program will be based in the Graduate School of Biomedical Sciences at Baylor College of Medicine which is headed by Dean William Brinkley. PERFORMANCE SITE ========================================Section End===========================================