This application proposes to develop a new Immunotoxicology Training Program based in the Department of Microbiology and Immunology at the West Virginia University Health Sciences Center. This new training program will offer students at West Virginia University opportunities for excellent training in immunotoxicology, which are based on a set of unique opportunities available at this institution. Most importantly, this training program will be led by three acknowledged leaders in the field of immunotoxicology. Dr. John B. Barnett is Chairperson of the Department of Microbiology and Immunology at West Virginia University and has been a national leader in understanding immunotoxic effects of organochlorine exposure. Dr. Albert Munson is Director of the Health Effects Laboratory Division of the National Institutes of Occupation Safety and Health (NIOSH), which is physically associated with the West Virginia University Health Sciences Center. Dr. Munson continues to provide expert guidance as one of the founding fathers of the field of immunotoxicology. Dr. Michael Luster is the Branch Chief of Immunotoxicology and Molecular Biology Branch of the Health Effects Laboratory of NIOSH. The combined resources of the West Virginia University Health Sciences Center and NIOSH provide a synergistic environment for training students and fellows in the context of both a state land-grant academic institution and a federally funded research institute focused on toxicology. Secondly, this Immunotoxicology Training Program will offer a new approach to investigation of toxic insult to the immune system. The design of the program is to first provide students with a thorough grounding in immunobiology that includes both basic and advanced course work, as well as specialized courses that are focused on fundamental principals of immunology. Subsequent training in toxicology will allow students to integrate these areas of study against a strong conceptual understanding of both fields. The investigators believe that this unique training paradigm will result in graduates from the program who will address the study of immunotoxicology with a stronger understanding of both the molecular and cellular basis of the immune response and the concepts of toxicology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES010953-04
Application #
6763025
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
2001-07-01
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
4
Fiscal Year
2004
Total Cost
$125,471
Indirect Cost
Name
West Virginia University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
Rowe, Alexander M; Brundage, Kathleen M; Barnett, John B (2008) Developmental immunotoxicity of atrazine in rodents. Basic Clin Pharmacol Toxicol 102:139-45
Salazar, Keith D; Ustyugova, Irina V; Brundage, Kathleen M et al. (2008) A review of the immunotoxicity of the pesticide 3,4-dichloropropionanalide. J Toxicol Environ Health B Crit Rev 11:630-45
Lewis, Tricia L; Brundage, Kathleen M; Brundage, Rodney A et al. (2008) 3,4-Dichloropropionanilide (DCPA) inhibits T-cell activation by altering the intracellular calcium concentration following store depletion. Toxicol Sci 103:97-107
Rowe, Alexander M; Brundage, Kathleen M; Barnett, John B (2007) In vitro atrazine-exposure inhibits human natural killer cell lytic granule release. Toxicol Appl Pharmacol 221:179-88
Walker, Valerie G; Ammer, Amanda; Cao, Zongxian et al. (2007) PI3K activation is required for PMA-directed activation of cSrc by AFAP-110. Am J Physiol Cell Physiol 293:C119-32
Clutter, Suzanne D; Fortney, James E; Gibson, Laura F (2006) Chemotherapy disrupts activity of translational regulatory proteins in bone marrow stromal cells. Exp Hematol 34:1522-31
Salazar, Keith D; Miller, Michael R; Barnett, John B et al. (2006) Evidence for a novel endocrine disruptor: the pesticide propanil requires the ovaries and steroid synthesis to enhance humoral immunity. Toxicol Sci 93:62-74
Rowe, Alexander M; Brundage, Kathleen M; Schafer, Rosana et al. (2006) Immunomodulatory effects of maternal atrazine exposure on male Balb/c mice. Toxicol Appl Pharmacol 214:69-77
Salazar, Keith D; de la Rosa, Patricia; Barnett, John B et al. (2005) The polysaccharide antibody response after Streptococcus pneumoniae vaccination is differentially enhanced or suppressed by 3,4-dichloropropionanilide and 2,4-dichlorophenoxyacetic acid. Toxicol Sci 87:123-33
Wang, Lin; Clutter, Suzanne; Benincosa, Jonathan et al. (2005) Activation of transforming growth factor-beta1/p38/Smad3 signaling in stromal cells requires reactive oxygen species-mediated MMP-2 activity during bone marrow damage. Stem Cells 23:1122-34

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