The proposed program will provide uninterrupted and continuing support for two years of postgraduate research training in the Health Sciences Division of Columbia University to qualified applicants who have completed their postgraduate clinical training in anesthesiology. The program will provide for three trainees, one or two in their fifth and two or one in their sixth postgraduate year. Research opportunities are offered by nineteen participating faculty members with proven records of success in the training of postdoctoral fellows, both within the Department of Anesthesiology as well as from seven collaborating departments, four in the basic sciences: Pharmacology, Physiology and Cellular Biophysics, Anatomy and Cell Biology, and the multidisciplinary Center for Neurobiology and Behavior, and three clinical departments: Medicine, Surgery, and Psychiatry. Research areas include, but are not limited to, modulation of neurotransmission by excitatory amino acids, acetylcholine receptors and ion channels, including calcium, the biology of inflammation and coagulation, neuronal mechanisms of behavior, cytokine biology, airway smooth muscle signaling, mechanisms of cocaine excitotoxicity, adenosine receptor physiology, and developmental autonomic receptor pharmacology. During the first year, the trainee will familiarize him or herself with the problems being investigated in the laboratory of the chosen participating faculty member, as well as the research techniques being used in that laboratory by participating in ongoing research projects. Toward the end of this period of assimilation it is expected that the trainee, with appropriate guidance, will formulate an independent project to be carried out largely during the second year of training, using procedures and techniques learned during the first year. With the continued support of the Department of Anesthesiology following training, this program will lead to the establishment of independent physician-investigators using modern methods and techniques to help meet the research needs of the specialty of anesthesiology in the twenty first century.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008464-11
Application #
6554521
Study Section
Special Emphasis Panel (ZGM1-BRT-2 (PD))
Program Officer
Cole, Alison E
Project Start
1992-07-01
Project End
2008-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
11
Fiscal Year
2003
Total Cost
$187,770
Indirect Cost
Name
Columbia University (N.Y.)
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Mikami, Maya; Perez-Zoghbi, Jose F; Zhang, Yi et al. (2018) Attenuation of Murine and Human Airway Contraction by a Peptide Fragment of the Cytoskeleton Regulatory Protein Gelsolin. Am J Physiol Lung Cell Mol Physiol :
Sonett, Jarrod; Goldklang, Monica; Sklepkiewicz, Piotr et al. (2018) A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure. FASEB J :fj201701381
Gonzalez Fiol, A; Meng, M-L; Danhakl, V et al. (2018) A study of factors influencing surgical cesarean delivery times in an academic tertiary center. Int J Obstet Anesth 34:50-55
Salling, Michael C; Skelly, Mary Jane; Avegno, Elizabeth et al. (2018) Alcohol Consumption during Adolescence in a Mouse Model of Binge Drinking Alters the Intrinsic Excitability and Function of the Prefrontal Cortex through a Reduction in the Hyperpolarization-Activated Cation Current. J Neurosci 38:6207-6222
Eisler, Lisa; Huang, Grace; Lee, Ka-Eun M et al. (2018) Identification of perioperative pulmonary aspiration in children using quality assurance and hospital administrative billing data. Paediatr Anaesth 28:218-225
Unachukwu, Uchenna; Trischler, Jordis; Goldklang, Monica et al. (2017) Maternal smoke exposure decreases mesenchymal proliferation and modulates Rho-GTPase-dependent actin cytoskeletal signaling in fetal lungs. FASEB J 31:2340-2351
Mikami, Maya; Zhang, Yi; Kim, Benjamin et al. (2017) Dexmedetomidine's inhibitory effects on acetylcholine release from cholinergic nerves in guinea pig trachea: a mechanism that accounts for its clinical benefit during airway irritation. BMC Anesthesiol 17:52
Skelly, M J; Ariwodola, O J; Weiner, J L (2017) Fear conditioning selectively disrupts noradrenergic facilitation of GABAergic inhibition in the basolateral amygdala. Neuropharmacology 113:231-240
Mikami, Maya; Zhang, Yi; Danielsson, Jennifer et al. (2017) Impaired Relaxation of Airway Smooth Muscle in Mice Lacking the Actin-Binding Protein Gelsolin. Am J Respir Cell Mol Biol 56:628-636
Harrison, Neil L; Skelly, Mary Jane; Grosserode, Emma K et al. (2017) Effects of acute alcohol on excitability in the CNS. Neuropharmacology 122:36-45

Showing the most recent 10 out of 57 publications