This training program was designed to prepare predoctoral students for careers in the area of genetics. The program is based in the Department of Molecular and Medical Genetics at Oregon Health Sciences University, and has a training faculty of 34 representing the Departments of Molecular and Medical Genetics, Molecular Microbiology and Immunology, Biochemistry and Molecular Biology, and Cell and Developmental Biology. The training faculty provides research opportunities in molecular, cellular, medical, developmental, population and quantitative genetics, biochemistry, cell and developmental biology. The training faculty's research areas encompass a broad range of research approaches some of which include gene isolation, production of animal models for human disease, techniques for studying gene expression, bioinformatics as well as quantitative and population based approaches for the study of human genetic disease. The students entering the Program in Molecular and Cellular Biosciences (PMCB) are selected based on performance as undergraduates, letters of recommendation, GRE scores, research experience and their commitment to a career in genetics research. During the first and second years, students take required and elective courses in eukaryotic genetics, prokaryotic genetics, cancer biology and genetics, biochemistry, and molecular, cellular and developmental biology. Included in the first and second years are student seminar courses in which students receive training and experience in the """"""""journal club"""""""" presentation of scientific information. Also during the first year, students participate in rotations in three """"""""PMCB"""""""" laboratories to provide students with initial experience in graduate level research, and to identify a mentor and a department for the thesis research requirement of the Ph.D. degree. Students also participate in other activities such as departmental seminars, Genetics Grand Rounds and Departmental and topic-driven journal clubs. In addition, students have access to the clinical labs that engage in diagnosis of and counseling on a variety of human genetic disorders. After choosing an advisor and passing the qualifying exam students become eligible for support from the training grant. The variety of opportunities available to the students allows the program to meet the goal of preparing young investigators for careers in biomedical research with heavy emphasis on the study of normal and abnormal genetic mechanisms.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008617-07
Application #
6622628
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Rhoades, Marcus M
Project Start
1997-07-01
Project End
2007-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
7
Fiscal Year
2003
Total Cost
$129,674
Indirect Cost
Name
Oregon Health and Science University
Department
Genetics
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Arnold, Hugh K; Zhang, Xiaoli; Daniel, Colin J et al. (2009) The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc. EMBO J 28:500-12
Junttila, Melissa R; Puustinen, Pietri; Niemela, Minna et al. (2007) CIP2A inhibits PP2A in human malignancies. Cell 130:51-62
Dai, Mu-Shui; Arnold, Hugh; Sun, Xiao-Xin et al. (2007) Inhibition of c-Myc activity by ribosomal protein L11. EMBO J 26:3332-45
Ma, J; Arnold, H K; Lilly, M B et al. (2007) Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A. Oncogene 26:5145-53
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Rizvi, Adnan Z; Swain, John R; Davies, Paige S et al. (2006) Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. Proc Natl Acad Sci U S A 103:6321-5
Arnold, Hugh K; Sears, Rosalie C (2006) Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation. Mol Cell Biol 26:2832-44
Houghtaling, Scott; Granville, Laura; Akkari, Yassmine et al. (2005) Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice. Cancer Res 65:85-91
Houghtaling, Scott; Newell, Amy; Akkari, Yassmine et al. (2005) Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining. Hum Mol Genet 14:3027-33
Yates, Phillip A; Burman, Robert; Simpson, James et al. (2003) Silencing of mouse Aprt is a gradual process in differentiated cells. Mol Cell Biol 23:4461-70

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