Abstract

This proposal seeks funding for continuation of a post doctoral training program in medical genetics designed to prepare individuals holding M.D., M.D./Ph.D., or Ph.D. degrees for independent research careers. During the past decade medical genetics has become integrated into the broad field of medicine. As a result of changes in this field, the Department of Genetics at Yale is receiving applications from medical specialists with previous clinical training in a variety of areas who are now seeking research training in genetics as well as more traditional candidates seeking both research and clinical training required for ABMG eligibility. Support is requested for a total of 4 stipends--2 for first-year fellows and 2 for second-year fellows. Typically, the program will fund two medical specialists per year who have completed most of their clinical training and wish to have a 2-year period of concentrated research in human genetics. Candidates seeking board eligibility in clinical genetics as well as research training will be supported from other sources during the bulk of clinical training. Most trainees will seek independent support for additional post doctoral training to make them more competitive for academic positions. In addition to M.D. candidates, a large number of applicants are recent graduates of Ph.D. programs seeking training in human genetics. It is anticipated that the program will accept a limited number of highly qualified Ph.D. applicants with a demonstrated commitment to human genetics research. The heart of this program will be participation in a research project under the direction of a primary preceptor and a committee made up of the director and other training faculty. Research areas supported by the training faculty include behavioral genetics, biochemical genetics, cancer genetics, cardiovascular genetics, cytogenetics, developmental genetics in humans and model organisms, genomics, immunogenetics, and population genetics. In addition a course in scientific integrity/medical ethics will be required and other course work will be tailored to the individual. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008753-09
Application #
7478164
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Haynes, Susan R
Project Start
2000-07-01
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2010-06-30
Support Year
9
Fiscal Year
2008
Total Cost
$150,962
Indirect Cost

  Institution

Name
Yale University
Department
Genetics
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Li, Peining; Pomianowski, Pawel; DiMaio, Miriam S et al. (2011) Genomic characterization of prenatally detected chromosomal structural abnormalities using oligonucleotide array comparative genomic hybridization. Am J Med Genet A 155A:1605-15
Martinez, Ivan; Cazalla, Demian; Almstead, Laura L et al. (2011) miR-29 and miR-30 regulate B-Myb expression during cellular senescence. Proc Natl Acad Sci U S A 108:522-7
Rossi, Michael R; DiMaio, Miriam S; Xiang, Bixia et al. (2009) Clinical and genomic characterization of distal duplications and deletions of chromosome 4q: study of two cases and review of the literature. Am J Med Genet A 149A:2788-94
Li, Peining; Zhang, Hui Z; Huff, Shannon et al. (2006) Karyotype-phenotype insights from 11q14.1-q23.2 interstitial deletions: FZD4 haploinsufficiency and exudative vitreoretinopathy in a patient with a complex chromosome rearrangement. Am J Med Genet A 140:2721-9
Busygina, Valeria; Kottemann, Molly C; Scott, Kenneth L et al. (2006) Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. Cancer Res 66:8397-403
Klein, Roger D; Thorland, Erik C; Gonzales, Patrick R et al. (2006) A multiplex assay for the detection and mapping of complex glycerol kinase deficiency. Clin Chem 52:1864-70
Zhang, Hui Z; Degar, Barbara A; Rogoulina, Svetlana et al. (2006) Hematopoiesis following disruption of the Pitx2 homeodomain gene. Exp Hematol 34:167-78
Klein, Roger D; Salih, Sana; Bessoni, Jesse et al. (2005) Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory. Genet Med 7:131-8
Klein, Roger D; Dykas, Daniel J; Bale, Allen E (2005) Clinical testing for the nevoid basal cell carcinoma syndrome in a DNA diagnostic laboratory. Genet Med 7:611-9
Zhang, Hui Z; Li, Peining; Wang, Dongmei et al. (2004) FOXC1 gene deletion is associated with eye anomalies in ring chromosome 6. Am J Med Genet A 124A:280-7

Showing the most recent 10 out of 17 publications