Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
1T32GM008763-01
Application #
6080244
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Preusch, Peter C
Project Start
2000-07-01
Project End
2005-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
1
Fiscal Year
2000
Total Cost
$252,118
Indirect Cost
Name
Johns Hopkins University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
DeColli, Alicia A; Nemeria, Natalia S; Majumdar, Ananya et al. (2018) Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria. J Biol Chem 293:10857-10869
Sanders, Sara; Vierling, Ryan J; Bartee, David et al. (2017) Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase. ACS Infect Dis 3:467-478
Seamon, Kyle J; Bumpus, Namandjé N; Stivers, James T (2016) Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer. Biochemistry 55:6087-6099
Calcaterra, Nicholas E; Hoeppner, Daniel J; Wei, Huijun et al. (2016) Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening. Sci Rep 6:19976
Seamon, Kyle J; Sun, Zhiqiang; Shlyakhtenko, Luda S et al. (2015) SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity. Nucleic Acids Res 43:6486-99
Seamon, Kyle J; Stivers, James T (2015) A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. J Biomol Screen 20:801-9
Seamon, Kyle J; Hansen, Erik C; Kadina, Anastasia P et al. (2014) Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization. J Am Chem Soc 136:9822-5
Hansen, Erik C; Seamon, Kyle J; Cravens, Shannen L et al. (2014) GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state. Proc Natl Acad Sci U S A 111:E1843-51
Kalu, Nene N; Desai, Prashant J; Shirley, Courtney M et al. (2014) Nelfinavir inhibits maturation and export of herpes simplex virus 1. J Virol 88:5455-61
Schonhoft, Joseph D; Kosowicz, John G; Stivers, James T (2013) Correction to DNA translocation by human uracil DNA glycosylase: role of DNA phosphate charge. Biochemistry 52:8599

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