This proposal requests funding for the predoctoral Chemical Biology Training Program at Stony Brook University (SBU). This interdisciplinary and interdepartmental Program offers chemical biology training opportunities for Ph.D. students selected from four participating units: the Biochemistry &Structural Biology, the Chemistry, the Molecular Genetics &Microbiology, and the Molecular &Cellular Pharmacology graduate programs. Participating faculty mentors (29) have research interests in infectious disease, cancer and toxicology, immunology, developmental biology, energy-harvesting, cell-signaling, organic synthesis, physical organic chemistry, enzymology, and materials chemistry. Trainees are educated in the principles and techniques of both chemistry and biology with a core interdisciplinary three-semester Chemical Biology course sequence. All trainees and mentors participate in the Institute of Chemical Biology and Drug Discovery annual symposium and poster session. This retreat is one avenue by which extensive interactions between students and faculty are fostered and the trainee group maintains a cohesive identity. The students meet for lunch with a Program Director or Mentor once per month during the academic year as a forum for feedback on careers, program assessment and two-way feedback. Trainees participate in their home graduate program research clubs and seminar series to broaden their knowledge and networking opportunities beyond the training program. In their fourth year, trainees work with Journalism faculty to convert their previously prepared research talks to presentations that non-scientists can understand and appreciate with the most compelling to be presented in a community outreach forum. Trainees invite outside seminar speakers. Instruction in the responsible conduct of research is carried out primarily through participation the course, """"""""Scientific Integrity"""""""". Recruitment of underrepresented groups is achieved through the SBU AGEP summer undergraduate research programs and extensive outreach. The number of mentors participating in the CBI Training Program is 29 and four funded positions are requested in the first year and eight funded positions are requested in subsequent years.

Public Health Relevance

Training of graduate students is essential for present and future discovery in biomedical research spanning cancer chemotherapy to new anti-infectives. This training program will provide students with training in chemical methods and biological methods that is necessary for developing new and better diagnostics and treatments for disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
1T32GM092714-01
Application #
7871608
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Fabian, Miles
Project Start
2010-07-01
Project End
2015-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
1
Fiscal Year
2010
Total Cost
$68,463
Indirect Cost
Name
State University New York Stony Brook
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Laptenok, Sergey P; Gil, Agnieszka A; Hall, Christopher R et al. (2018) Infrared spectroscopy reveals multi-step multi-timescale photoactivation in the photoconvertible protein archetype dronpa. Nat Chem 10:845-852
Victor, Tiffany W; Easthon, Lindsey M; Ge, Mingyuan et al. (2018) X-ray Fluorescence Nanotomography of Single Bacteria with a Sub-15?nm Beam. Sci Rep 8:13415
Roth, Eric; Frohman, Michael A (2018) Proliferative and metastatic roles for Phospholipase D in mouse models of cancer. Adv Biol Regul 67:134-140
Guo, Jiaye; Collins, Stephen; Miller, W Todd et al. (2018) Identification of a Water-Coordinating HER2 Inhibitor by Virtual Screening Using Similarity-Based Scoring. Biochemistry 57:4934-4951
Kumar, Pratik; Jiang, Ting; Zainul, Omar et al. (2018) Lipidated cyclopropenes via a stable 3-N spirocyclopropene scaffold. Tetrahedron Lett 59:3435-3438
Zhang, Zhuo; Ordonez, Alvaro A; Wang, Hui et al. (2018) Positron Emission Tomography Imaging with 2-[18F]F- p-Aminobenzoic Acid Detects Staphylococcus aureus Infections and Monitors Drug Response. ACS Infect Dis 4:1635-1644
Lu, Hao; Iuliano, James N; Tonge, Peter J (2018) Structure-kinetic relationships that control the residence time of drug-target complexes: insights from molecular structure and dynamics. Curr Opin Chem Biol 44:101-109
Hossain, Sajjad; Heckler, Ilana; Boon, Elizabeth M (2018) Discovery of a Nitric Oxide Responsive Quorum Sensing Circuit in Vibrio cholerae. ACS Chem Biol 13:1964-1969
Williams, Dominique E; Nisbett, Lisa-Marie; Bacon, Bezalel et al. (2018) Bacterial Heme-Based Sensors of Nitric Oxide. Antioxid Redox Signal 29:1872-1887
Preston, Alyssa N; Farr, Joshua D; Tan, Kevin C et al. (2018) Design principles for cationic, astrocyte-targeted probes. Chembiochem :

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