Description) The main goal of this program is to provide interdisciplinary training in the neural bases of motor dysfunction and rehabilitation. The intent is to prepare post-doctoral trainees for independent basic and clinical research careers in rehabilitation sciences. The interdisciplinary nature of this program is unique in that basic science trainees will have the opportunity to participate in clinical aspects of rehabilitative medicine, and clinical trainees will be provided with valuable basic scientific insights and technical experience into the neural bases of motor impairment and recovery from brain injury. The training program will focus on the following three general research themes that form the focal points of a model of motor recovery across the lifespan: (1) characterization of impairments and recovery, (2) rehabilitative interventions, (3) pharmacologic interventions. These three themes will utilize expertise from both basic and clinical research to cross-fertilize research experiences of the individual trainees. The goal of the program is to provide trainees in rehabilitative sciences experience with the complex interdisciplinary models that will be necessary for the next generation of therapeutic approaches in rehabilitative medicine. The core faculty include two clinical researchers and five basic science researchers. Five of the faculty are members of the Mental Retardation Research Center (MRRC), and two have their laboratories in close proximity to one another in the KU-Med Center MRRC. The strength of this group is its focus on motor disabilities and understanding their neural underpinnings. The unifying themes of the faculty and students who participate in the proposed training program is a common interest in the life-long development and function of the brain in both health and disease and the design of approaches to treat abnormal conditions of brain function through the use of behavioral training, through novel drug therapies, or through rehabilitative/pharmacologic interactions. The recruitment and selection of trainees will be coordinated through a program advisory committee, with input from all the participating faculty. Trainees with an M.D. or Ph.D. degree in one of the basic or clinical sciences, or an equivalent degree, and a strong commitment to interdisciplinary research in rehabilitation sciences will be considered for entry into this program. Laboratory research and apprenticeships, courses, seminars, guest lectures, journal clubs, data sessions, and poster presentations will be utilized to ensure frequent interaction of the trainees and faculty from the different research areas.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007523-03
Application #
6476667
Study Section
Special Emphasis Panel (ZHD1-DRG-A (LN))
Program Officer
Nitkin, Ralph M
Project Start
2000-07-01
Project End
2005-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
3
Fiscal Year
2002
Total Cost
$72,291
Indirect Cost
Name
University of Kansas
Department
Physiology
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Fuentes, Isabella M; Walker, Natalie K; Pierce, Angela N et al. (2016) Neonatal maternal separation increases susceptibility to experimental colitis and acute stress exposure in male mice. IBRO Rep 1:10-18
Fuentes, I M; Christianson, J A (2016) Ion channels, ion channel receptors, and visceral hypersensitivity in irritable bowel syndrome. Neurogastroenterol Motil 28:1613-1618
Cao, Zubing; Carey, Timothy S; Ganguly, Avishek et al. (2015) Transcription factor AP-2? induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage. Development 142:1606-15
Russell, K L; Berman, N E J; Gregg, P R A et al. (2014) Fish oil improves motor function, limits blood-brain barrier disruption, and reduces Mmp9 gene expression in a rat model of juvenile traumatic brain injury. Prostaglandins Leukot Essent Fatty Acids 90:5-11
Russell, Kristin L; Berman, Nancy E J; Levant, Beth (2013) Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. Prostaglandins Leukot Essent Fatty Acids 89:97-105
Barbay, Scott; Zoubina, Elena V; Dancause, Numa et al. (2006) A single injection of D-amphetamine facilitates improvements in motor training following a focal cortical infarct in squirrel monkeys. Neurorehabil Neural Repair 20:455-8
Quaney, Barbara M; Perera, Subashan; Maletsky, Rebecca et al. (2005) Impaired grip force modulation in the ipsilesional hand after unilateral middle cerebral artery stroke. Neurorehabil Neural Repair 19:338-49