This is a new application for an Institutional Research Training Grant within the Department of Pediatrics at Washington University School of Medicine. The long-term objective is to foster the growth and development of physician-scientists in Newborn Medicine and Developmental Biology.
The specific aim of this proposal is to utilize the unique resources of the institution, including the Developmental Biology Group in the Department of Pediatrics and the Developmental Biology Program in the Division of Biology and Biomedical Sciences, to establish a training program with a participating faculty of pediatricians and basic scientists who share common interests and frequent investigative and scholarly interactions. The program is intended to provide funding for an initial two years of laboratory investigation and emphasizes the application of cell and molecular biologic approaches to address fundamental issues in the most important problems of newborn infants. Sufficient space and resources are available, and trainees will benefit from the numerous educational activities within the institution, including didactic coursework as well as journal clubs and seminars in the basic sciences. The program directors will utilize an executive committee to obtain continuing advice with respect to the operation of the program as well as to select candidate trainees, identify appropriate mentors, and review scholarly progress. The substantive collaboration of established pediatric physician-scientists and basic investigators pursuing questions in developmental biology provides a unique opportunity for the training of selected individuals in the application of fundamental experimental methods to the treatment and prevention of diseases of the newborn infant. As such, this program should provide for new pediatric scholars to lead the way for future advances in this important area of child health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD041925-04
Application #
6877181
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (32))
Program Officer
Higgins, Rosemary
Project Start
2002-05-01
Project End
2007-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
4
Fiscal Year
2005
Total Cost
$115,350
Indirect Cost
Name
Washington University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Spinelli, Matthew A; Ponath, Claudia; Tieu, Lina et al. (2017) Factors associated with substance use in older homeless adults: Results from the HOPE HOME study. Subst Abus 38:88-94
Wambach, Jennifer A; Yang, Ping; Wegner, Daniel J et al. (2010) Surfactant protein-C promoter variants associated with neonatal respiratory distress syndrome reduce transcription. Pediatr Res 68:216-20
McBee, Amy D; Wegner, Daniel J; Carlson, Christopher S et al. (2008) Recombination as a mechanism for sporadic mutation in the surfactant protein-C gene. Pediatr Pulmonol 43:443-50
Gomperts, Brigitte N; Kim, Linda J; Flaherty, Scott A et al. (2007) IL-13 regulates cilia loss and foxj1 expression in human airway epithelium. Am J Respir Cell Mol Biol 37:339-46
Garmany, Tami H; Moxley, Michael A; White, Frances V et al. (2006) Surfactant composition and function in patients with ABCA3 mutations. Pediatr Res 59:801-5
Zhang, Min; Bolfing, Mary F; Knowles, Heather J et al. (2004) Foxj1 regulates asymmetric gene expression during left-right axis patterning in mice. Biochem Biophys Res Commun 324:1413-20