The purpose of this application is to establish a post-doctoral training program in the Mental Retardation and Developmental Disabilities (MRDD) Research Center at the Children's Research Institute, of Children's National Medical Center (CNMC) in Washington, D.C. The focus of this program will be on five areas of inquiry associated with MRDD: autism, learning disabilities (developmental dyslexia), traumatic brain injury, epilepsy, and urea cycle disorders. This will be a multidisciplinary effort that draws on 14 faculty preceptors in the areas of neuroscience, neurobehavioral science and genetics from seven Departments at CNMC and Georgetown University School of Medicine. CNMC is particularly well positioned to lead this program, based on: i) its strengths in basic, translational and clinical research, and in mentorship in all the proposed areas of inquiry; ii) its established strong collaborations with Georgetown University, and iii) its leading role in a number of NIH Center Grants focusing on conditions causing MRDD. We propose to enter 2 postdoctoral trainees (MD and PhD) per year in the 3 year training program. A unique aspect of the training will be that each area of inquiry will have genetic, neuroscience and neurobehavioral components, and each fellow will chose a mentor's laboratory that focuses on one of these areas but will rotate through each component to acquire Interdisciplinary training in the specific disorder being studied. The objectives of the program are to encourage MD's to develop as researchers in the field of MRDD and to stimulate greater participation of promising PhD researchers in this area. Each trainee will be carefully mentored through the program to ensure that he/she fully exploits the range of opportunities of the program. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD046388-03
Application #
7414052
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Oster-Granite, Mary Lou
Project Start
2006-05-01
Project End
2011-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
3
Fiscal Year
2008
Total Cost
$232,833
Indirect Cost
Name
Children's Research Institute
Department
Type
DUNS #
143983562
City
Washington
State
DC
Country
United States
Zip Code
20010
Smith, Nathan A; Kress, Benjamin T; Lu, Yuan et al. (2018) Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions. Sci Signal 11:
Li, Peijun; Fu, Xiaoqin; Smith, Nathan A et al. (2017) Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy. Neuron 96:387-401.e6
Sepeta, Leigh N; Casaletto, Kaitlin Blackstone; Terwilliger, Virginia et al. (2017) The role of executive functioning in memory performance in pediatric focal epilepsy. Epilepsia 58:300-310
Ratto, Allison B; Anthony, Bruno J; Pugliese, Cara et al. (2017) Lessons learned: Engaging culturally diverse families in neurodevelopmental disorders intervention research. Autism 21:622-634
Frankel, Sari; Medvedeva, Natalia; Gutherz, Samuel et al. (2016) Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats. Epilepsy Behav 57:34-40
Wallace, Gregory L; Kenworthy, Lauren; Pugliese, Cara E et al. (2016) Real-World Executive Functions in Adults with Autism Spectrum Disorder: Profiles of Impairment and Associations with Adaptive Functioning and Co-morbid Anxiety and Depression. J Autism Dev Disord 46:1071-83
Kaushal, Suhasini; Tamer, Zenab; Opoku, Freda et al. (2016) Anticonvulsant drug-induced cell death in the developing white matter of the rodent brain. Epilepsia 57:727-34
Pugliese, Cara E; Anthony, Laura Gutermuth; Strang, John F et al. (2016) Longitudinal Examination of Adaptive Behavior in Autism Spectrum Disorders: Influence of Executive Function. J Autism Dev Disord 46:467-77
Sepeta, Leigh N; Berl, Madison M; Wilke, Marko et al. (2016) Age-dependent mesial temporal lobe lateralization in language fMRI. Epilepsia 57:122-30
Forcelli, Patrick A; DesJardin, Jacqueline T; West, Elizabeth A et al. (2016) Amygdala selectively modulates defensive responses evoked from the superior colliculus in non-human primates. Soc Cogn Affect Neurosci 11:2009-2019

Showing the most recent 10 out of 39 publications