Over the past 10 years there have been several reports concerned with the lack of sufficient basic research in the clinical departments. Research training in reproduction is targeted as one of five needed Program areas within the National Institute of Child Health and Human Development. It is our goal, through this Training Program is to recruit qualified Ph.D. scientists to undergo postdoctoral training in Reproductive Science and to facilitate their career development and retention in this field. The long-term objective of this application is to take advantage of the significant resources and experience within the Department of OB/GYN to train and promote the development of future leaders in the reproductive sciences with dual strengths in basic and clinical research.
Our specific aim i n this program is to select and recruit talented, postdoctoral fellows and offer a research training position in the laboratory of a highly qualified mentor. The research program is built upon collaborative efforts among nine faculty mentors in three subgroups: molecular reproductive endocrinology, biology and maternal-fetal interactions, and gynecologic oncology. Thus, this highly structured Program will allow trainees the opportunity to mature as a multi-faceted reproductive scientist in a superb scientific setting at Washington University. Trainees will actively participate in ongoing research in a laboratory under the mentor's supervision. In addition, resources of the department and the medical campus are incorporated in this Program as career development tools for trainees, such as grant and manuscript writing and career development within the collaborative efforts of mentors highly committed to and experienced in postdoctoral training. The newly founded Office of Post Graduate Affairs at Washington University School of Medicine also provides excellent support and resources to these individuals. Our active Minority Recruitment plan covers detailed strategies and outlines our rigorous efforts at this important component. If successful in our aim, this Program will produce well-trained and competitive reproductive scientists who will pursue clinical, evidence-based questions with a solid, basic science-derived approach.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD049305-03
Application #
7233966
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
2005-05-01
Project End
2010-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
3
Fiscal Year
2007
Total Cost
$102,289
Indirect Cost
Name
Washington University
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Crofts, Terence S; Wang, Bin; Spivak, Aaron et al. (2018) Shared strategies for ?-lactam catabolism in the soil microbiome. Nat Chem Biol 14:556-564
Crofts, Terence S; Gasparrini, Andrew J; Dantas, Gautam (2017) Next-generation approaches to understand and combat the antibiotic resistome. Nat Rev Microbiol 15:422-434
Crofts, Terence S; Wang, Bin; Spivak, Aaron et al. (2017) Draft Genome Sequences of Three ?-Lactam-Catabolizing Soil Proteobacteria. Genome Announc 5:
Bauckman, Kyle A; Mysorekar, Indira U (2016) Ferritinophagy drives uropathogenic Escherichia coli persistence in bladder epithelial cells. Autophagy 12:850-63
Gasparrini, Andrew J; Crofts, Terence S; Gibson, Molly K et al. (2016) Antibiotic perturbation of the preterm infant gut microbiome and resistome. Gut Microbes 7:443-9
Owusu-Boaitey, Nana; Bauckman, Kyle A; Zhang, Tingxuan et al. (2016) Macrophagic control of the response to uropathogenic E. coli infection by regulation of iron retention in an IL-6-dependent manner. Immun Inflamm Dis 4:413-426
Saben, Jessica L; Boudoures, Anna L; Asghar, Zeenat et al. (2016) Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations. Cell Rep 16:1-8
Saben, Jessica L; Asghar, Zeenat; Rhee, Julie S et al. (2016) Excess Maternal Fructose Consumption Increases Fetal Loss and Impairs Endometrial Decidualization in Mice. Endocrinology 157:956-68
Roszko, Isabelle; S Sepich, Diane; Jessen, Jason R et al. (2015) A dynamic intracellular distribution of Vangl2 accompanies cell polarization during zebrafish gastrulation. Development 142:2508-20
Gibson, Molly K; Crofts, Terence S; Dantas, Gautam (2015) Antibiotics and the developing infant gut microbiota and resistome. Curr Opin Microbiol 27:51-6

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