The overall goal of the proposed Program is to provide comprehensive and in-depth research training in the reproductive sciences centrally integrating training in the tools of functional mammalian genomics and genetics. To accomplish this goal, a select group of graduate and postdoctoral trainees will have the opportunity to choose and be trained by dual mentors;the primary trainer having expertise in the reproductive sciences and the co-trainer with expertise in genomics. Nineteen faculty trainers are represented in this application. We are requesting support for three baccalaureate Ph.D. slots and two postdoctoral slots, each for a 2 year training interval. Support is requested for a total of 5 years for this new Training Program. The philosophy behind this proposed training plan is based upon the appreciation that biomedical researchers in the reproductive sciences would benefit greatly from parallel training in practical and applied use of genome-wide investigative techniques. Cornell University is uniquely poised for a training program in reproductive sciences that spans male and female physiology, the genetic bases of fertility, the immunological basis of the maternal-fetal interface, cell signaling and molecular endocrinology and the molecular and genetic basis for reproductive cancers. In addition, the proposed Program will benefit greatly by inclusion of faculty members with interests in non-mammalian models of reproduction in Drosophila and C. elegans to facilitate comparative evolutionary studies. Training in the genomics area will emphasize the following (some examples): creation and use of transgenic and knock out models (animal models for the study of fertility as well as models of disease pathophysiology emphasizing reproductive neoplasia);use of micro arrays and bioinformatics analyses including comprehensive training in manipulation of databases for model organisms and genomic browsers/portals that serve to aid in determination of genotype/phenotype relationships;creation of computer-based modeling to facilitate informed decisions on structure/function relationships;analysis of gene transcription networks based upon application of principles of comparative genomics. The faculty members involved in this proposed Program are committed to facilitating a training environment in the reproductive sciences and its interface with genome structure and activity. The collaborative effort(s) between trainers and co-trainers is the cornerstone of this Program. This unique scientific and technical interface will enhance the opportunity for pre- and postdoctoral trainees to leave this environment well-trained in the reproductive sciences and in multiple state-of-the-art techniques and applications in genomics that will optimize their continued success in continued training (transitioning to postdoctoral) or the acquisition of scientific positions in academia, government or industry.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD052471-05
Application #
8068011
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
2007-09-30
Project End
2012-09-16
Budget Start
2011-05-01
Budget End
2012-09-16
Support Year
5
Fiscal Year
2011
Total Cost
$226,731
Indirect Cost
Name
Cornell University
Department
Other Basic Sciences
Type
Schools of Veterinary Medicine
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Villarreal, Susan M; Pitcher, Sylvie; Helinski, Michelle E H et al. (2018) Male contributions during mating increase female survival in the disease vector mosquito Aedes aegypti. J Insect Physiol 108:1-9
Fu, Dah-Jiun; Miller, Andrew D; Southard, Teresa L et al. (2018) Stem Cell Pathology. Annu Rev Pathol 13:71-92
Avila, Frank W; Wolfner, Mariana F (2017) Cleavage of the Drosophila seminal protein Acp36DE in mated females enhances its sperm storage activity. J Insect Physiol 101:66-72
Villarreal, Susan M; Winokur, Olivia; Harrington, Laura (2017) The Impact of Temperature and Body Size on Fundamental Flight Tone Variation in the Mosquito Vector Aedes aegypti (Diptera: Culicidae): Implications for Acoustic Lures. J Med Entomol 54:1116-1121
Liu, Yi; Cussiol, José Renato; Dibitetto, Diego et al. (2017) TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9. J Cell Biol 216:623-639
Liu, Xiaoqiu; Morency, Eric; Li, Tingting et al. (2017) Role for PADI6 in securing the mRNA-MSY2 complex to the oocyte cytoplasmic lattices. Cell Cycle 16:360-366
Migone, Fernando F; Hung, Pei-Hsuan; Cowan, Robert G et al. (2017) Overactivation of hedgehog signaling in the developing Müllerian duct interferes with duct regression in males and causes subfertility. Reproduction 153:481-492
Hilz, Stephanie; Fogarty, Elizabeth A; Modzelewski, Andrew J et al. (2017) Transcriptome profiling of the developing male germ line identifies the miR-29 family as a global regulator during meiosis. RNA Biol 14:219-235
Delbare, Sofie Y N; Chow, Clement Y; Wolfner, Mariana F et al. (2017) Roles of Female and Male Genotype in Post-Mating Responses in Drosophila melanogaster. J Hered 108:740-753
Pierpont, Timothy M; Lyndaker, Amy M; Anderson, Claire M et al. (2017) Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer. Cell Rep 21:1896-1909

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