This is an application for renewal of a training program in cellular and integrative neuroscience at the University of Maryland, Baltimore (UMB), School of Medicine. The goal of the program is to provide multidisciplinary training to postdoctoral fellows based on the philosophy that neuroscientists require expertise in many facets of integrative neuroscience in order to participate effectively in advanced investigations of the nervous system. Cellular communication is central to the integrative properties of the nervous system and plasticity of communication is increasingly recognized as a broad fundamental principle; indeed, plasticity of communication is the organizing theme of the program. Six interactive interest groups, representing the research strengths of the program faculty, constitute focal points for investigation and training. These interest groups are: 1) neural systems, 2) intercellular communication, 3) molecular factors in cell signaling, 4) developmental neuroscience, 5) glia, and 6) novel optical approaches in neuroscience. The program steering committee, an interdepartmental group of five senior investigators, is responsible for the administrative operation of the program including evaluating applicants and awarding stipends, monitoring trainee progress, coordinating recruitment efforts, and conducting an annual retreat. The steering committee and 15 additional established neuroscientists with long-standing track records of publications, successful postdoctoral training experience and extramural funding, constitute the primary faculty in whom rests the principal responsibility for supervision of trainees: 8 secondary faculty members collaborate with the primary faculty in research and training. In light of the explosive growth of outstanding neuroscience research at UMB, consistent success in competing for NIH funding and the large number of excellent postdoctoral fellows already trained by program faculty, this application requests support for seven fellows.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
2T32NS007375-11
Application #
6803711
Study Section
Special Emphasis Panel (ZNS1-SRB-M (01))
Program Officer
Porter, Linda L
Project Start
1994-09-15
Project End
2009-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
11
Fiscal Year
2004
Total Cost
$371,703
Indirect Cost
Name
University of Maryland Baltimore
Department
Physiology
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
LeGates, Tara A; Kvarta, Mark D; Tooley, Jessica R et al. (2018) Reward behaviour is regulated by the strength of hippocampus-nucleus accumbens synapses. Nature 564:258-262
Kahraman, Sibel; Siegel, Alex; Polster, Brian M et al. (2015) Permeability transition pore-dependent and PARP-mediated depletion of neuronal pyridine nucleotides during anoxia and glucose deprivation. J Bioenerg Biomembr 47:53-61
Fischell, Jonathan; Van Dyke, Adam M; Kvarta, Mark D et al. (2015) Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors. Neuropsychopharmacology 40:2499-509
Thompson, Scott M; Kallarackal, Angy J; Kvarta, Mark D et al. (2015) An excitatory synapse hypothesis of depression. Trends Neurosci 38:279-94
Milstein, Jean A; Elnabawi, Ahmed; Vinish, Monika et al. (2013) Olanzapine treatment of adolescent rats causes enduring specific memory impairments and alters cortical development and function. PLoS One 8:e57308
Vinish, Monika; Elnabawi, Ahmed; Milstein, Jean A et al. (2013) Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function. Int J Neuropsychopharmacol 16:1599-609
Schwartz, Michael D; Mong, Jessica A (2013) Estradiol modulates recovery of REM sleep in a time-of-day-dependent manner. Am J Physiol Regul Integr Comp Physiol 305:R271-80
Lenz, Kathryn M; Nugent, Bridget M; Haliyur, Rachana et al. (2013) Microglia are essential to masculinization of brain and behavior. J Neurosci 33:2761-72
Laird, Melissa D; Clerc, Pascaline; Polster, Brian M et al. (2013) Augmentation of normal and glutamate-impaired neuronal respiratory capacity by exogenous alternative biofuels. Transl Stroke Res 4:643-51
Kerr, Jaclyn P; Ziman, Andrew P; Mueller, Amber L et al. (2013) Dysferlin stabilizes stress-induced Ca2+ signaling in the transverse tubule membrane. Proc Natl Acad Sci U S A 110:20831-6

Showing the most recent 10 out of 55 publications