Neurobiology of Disease Training Program

Price, Donald L.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Institutional National Research Service Award (T32)
• Project #: 5T32NS007435-05
• Application #: 6530990
• Study Section: NST-2 Subcommittee (NST)
• Program Officer: Oliver, Eugene J
• Project Start: 1998-07-01
• Project End: 2004-06-30
• Budget Start: 2002-07-01
• Budget End: 2004-06-30
• Support Year: 5
• Fiscal Year: 2002
• Total Cost: $226,112

Institution

• Name: Johns Hopkins University
• Department: Pathology
• Type: Schools of Medicine
• DUNS #: 045911138
• City: Baltimore
• State: MD
• Country: United States
• Zip Code: 21218

Publications

Jankowsky, Joanna L; Fadale, Daniel J; Anderson, Jeffrey et al. (2004) Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 13:159-70

Jankowsky, Joanna L; Slunt, Hilda H; Gonzales, Victoria et al. (2004) APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1. Neurobiol Aging 25:885-92

Sheng, Jin G; Price, Donald L; Koliatsos, Vassilis E (2003) The beta-amyloid-related proteins presenilin 1 and BACE1 are axonally transported to nerve terminals in the brain. Exp Neurol 184:1053-7

Sheng, Jin G; Bora, Susan H; Xu, G et al. (2003) Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice. Neurobiol Dis 14:133-45

Sheng, Jin G; Price, Donald L; Koliatsos, Vassilis E (2002) Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. J Neurosci 22:9794-9