We propose an integrated program to provide research training program in molecular-mechanism-based biomedical research to veterinarians with residency training in comparative medicine, pathology, microbiology, oncology, or other post-DVM specialty training. The training program will comprise: (a) an initial phase of residency specialty training funded by the sponsoring institution, followed by, (b) mentored research training funded by the NCRR T32 mechanism providing concentrated mentored research training emphasizing primary bench research employing modern multidisciplinary methodologies and featuring critical thinking in experimental design, data interpretation, scientific writing, communication skills, and ethical conduct of research. Candidates having completed residency experience at another institution will enter the research training phase immediately. Key elements of the program are: Integration of CSU-funded residency training with NCRR-sponsored research training. Emphasis on contemporary research training to equip candidates to become principal investigators. A mentor faculty of NIH-funded principal investigators with substantial experience in graduate training. A Program Director with extensive experience in research training of veterinarians. An External Advisory Committee comprised of T32 Program Directors who bring first-hand knowledge of effective post-DVM training and successful NCRR training programs. ? We believe the program is aligned with contemporary NCRR and DCM objectives, equips trainees to ? become successful NIH-funded investigators and collaborators, and represents an effective investment to generate currently undersupplied and uniquely-trained investigators to advance national health and ? biosecurity priorities. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Institutional National Research Service Award (T32)
Project #
5T32RR007072-07
Application #
7430413
Study Section
Special Emphasis Panel (ZRR1-CM-9 (02))
Program Officer
Watson, William T
Project Start
2000-07-01
Project End
2012-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
7
Fiscal Year
2008
Total Cost
$321,074
Indirect Cost
Name
Colorado State University-Fort Collins
Department
Microbiology/Immun/Virology
Type
Schools of Veterinary Medicine
DUNS #
785979618
City
Fort Collins
State
CO
Country
United States
Zip Code
80523
Soffler, Carl; Bosco-Lauth, Angela M; Aboellail, Tawfik A et al. (2014) Pathogenesis of percutaneous infection of goats with Burkholderia pseudomallei: clinical, pathologic, and immunological responses in chronic melioidosis. Int J Exp Pathol 95:101-19
Podell, Brendan K; Ackart, David F; Obregon-Henao, Andres et al. (2014) Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity. Am J Pathol 184:1104-1118
Webb, Brett T; McGilvray, Kirk C; Smirnova, Natalia P et al. (2013) Effects of in utero pestivirus infection on bovine fetal bone geometry, biomechanical properties and composition. Vet J 198:376-81
Hafeman, S D; Varland, D; Dow, S W (2012) Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. Vet Comp Oncol 10:44-56
Soffler, Carl; Bosco-Lauth, Angela M; Aboellail, Tawfik A et al. (2012) Development and characterization of a caprine aerosol infection model of melioidosis. PLoS One 7:e43207
Webb, B T; Norrdin, R W; Smirnova, N P et al. (2012) Bovine viral diarrhea virus cyclically impairs long bone trabecular modeling in experimental persistently infected fetuses. Vet Pathol 49:930-40
Wittenburg, Luke A; Ptitsyn, Andrey A; Thamm, Douglas H (2012) A systems biology approach to identify molecular pathways altered by HDAC inhibition in osteosarcoma. J Cell Biochem 113:773-83
Wittenburg, Luke A; Bisson, Liam; Rose, Barbara J et al. (2011) The histone deacetylase inhibitor valproic acid sensitizes human and canine osteosarcoma to doxorubicin. Cancer Chemother Pharmacol 67:83-92
Seelig, Davis M; Mason, Gary L; Telling, Glenn C et al. (2011) Chronic wasting disease prion trafficking via the autonomic nervous system. Am J Pathol 179:1319-28
Kurt, Timothy D; Seelig, Davis M; Schneider, Jay R et al. (2011) Alteration of the chronic wasting disease species barrier by in vitro prion amplification. J Virol 85:8528-37

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