Thegoalofthiscompetitiverenewalapplicationistoprovideavarietyofcomplementarytrainingopportunities indentalandcraniofacialresearchattheUniversityofIowa(UI)andtodevelopacohortofbasicresearchers anddentalscholarswhoseinvestigativeskillswillmeetthechallengesoforalhealthresearchforthe21st century.
The aims aretopreparetraineesformeaningfulcareersinoralhealthresearchandacademicsby providingoutstandinginterdisciplinarydidactictrainingandrigorousresearchmentoringexperiences emphasizingongoingreviewandcritique.Theproposedprogramcontinuation,buildingon30+yearsof researchtrainingsuccess,hasafocusondentalgraduates,butrecognizesthatbasicscientistsalsoplay importantrolesinoralhealthresearch;?thus,itwillalsooffertrainingopportunitiesfornon-dentists.TheR90 componentreflectstheincreasinglyimportantrolethatinternationaldentistshave,andwillcontinuetohave,in ouroralhealthresearchprograms.Thefivemajorresearchareasinwhichtrainingisoffered,1) Bioengineering,TissueEngineering,StemCells,Biomaterials,andMaterialsResearch2)Immunology, Inflammation,Microbiology,Caries,andMicrobiomeResearch3)Craniofacial,OralBiology,Genetics,and DentalDevelopmentResearch4)PublicHealth,EpidemiologyandBehavioralSciences,and5)OralHealth PolicyResearch,reflectthestrengthsoftheCollegeofDentistry,thehealthsciencecolleges,UIinstitutesand centersandrangeacrossthefulltranslationalspectrum.Specifically,weoffertrainingfordentistsandnon- dentiststopursueaPhDinOralSciences(orinoneofthesixotherPhDprogramsfromwhichwewillrecruit, asappropriate),ortopursuepost-doctoraltraining.Inaddition,therewillbeanopportunitytoobtaina CertificateinTranslationalandClinicalInvestigationundertheauspicesoftheUIInstituteforClinicaland TranslationalSciences(ourCTSA-fundedinstitute).Agroupof28experiencedandtalentedprogramfaculty fromavarietyofdisciplinesisavailabletomentortrainees.Trainingwillbesupervisedbyanexperienced DirectorandAssociateDirector,assistedbyaFacultyLeadershipteam.Theprogramwillhaveinternaland externaladvisorycommittees,anewly-establishedGrant-writingCommittee,anewly-establishedFaculty MentoringProgram,andaCommitteeonRecruitmentandDiversity.Insummary,theprogrambringstogether productive,well-fundedmentorswithpre-andpost-doctoraltraineesinanenvironmentwithastrong institutionalcommitmenttodevelopoutstandinginterdisciplinaryresearchtraining,astronginstitutionalrecord oftraininginrelevantdisciplines,andexcellenteducationalandresearchfacilities.Theoutcomewillcontinue tobethedevelopmentofacadreoforalhealthresearchersequippedtofunctionatthecuttingedgeoftheir disciplines.

Public Health Relevance

The proposed continuation of our training program is designed to provide training opportunities at the PhD and post-doctoral levels for both dentist and non-dentist scientists, including training in translational and clinical research. This program is designed to allow trainees to develop the complex skills necessary to undertake independent and collaborative research, and thus to become dental scholars capable of meeting future opportunities and challenges in dental education and oral health research nationwide.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Interdisciplinary Research Training Award (T90)
Project #
5T90DE023520-08
Application #
9966961
Study Section
Special Emphasis Panel (ZDE1)
Program Officer
King, Lynn M
Project Start
2013-07-01
Project End
2023-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
8
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Iowa
Department
Dentistry
Type
Schools of Dentistry/Oral Hygn
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
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Garaicoa, Jorge L; Fischer, Carol L; Bates, Amber M et al. (2018) Promise of Combining Antifungal Agents in Denture Adhesives to Fight Candida Species Infections. J Prosthodont 27:755-762
Raina, Monica; Bates, Amber M; Fischer, Carol L et al. (2018) Human beta defensin 3 alters matrix metalloproteinase production in human dendritic cells exposed to Porphyromonas gingivalis hemagglutinin B. J Periodontol 89:361-369
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Liu, Huan; Busch, Tamara; Eliason, Steven et al. (2017) Exome sequencing provides additional evidence for the involvement of ARHGAP29 in Mendelian orofacial clefting and extends the phenotypic spectrum to isolated cleft palate. Birth Defects Res 109:27-37
Bates, Amber M; Lanzel, Emily A; Qian, Fang et al. (2017) Cell genomics and immunosuppressive biomarker expression influence PD-L1 immunotherapy treatment responses in HNSCC-a computational study. Oral Surg Oral Med Oral Pathol Oral Radiol 124:157-164
Weaver, Cole A; Miller, Steven F; da Fontoura, Clarissa S G et al. (2017) Candidate gene analyses of 3-dimensional dentoalveolar phenotypes in subjects with malocclusion. Am J Orthod Dentofacial Orthop 151:539-558
Villhauer, Alissa L; Lynch, David J; Warren, John J et al. (2017) Genotypic characterization and comparison of Streptococcus mutans in American Indian and Southeast Iowa children. Clin Exp Dent Res 3:235-243

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