Abstract

The goal of this interdisciplinary training program is to train future leaders in Regenerative Medicine. The new discipline of Regenerative Medicine has arisen at the intersection of the frontiers of research in Developmental Biology, Bioengineering, and Clinical Medicine. This Program is truly interdisciplinary in nature and will expose trainees to Developmental Biology, Bioengineering, and the clinical consequences of tissue deficiencies/dysfunction in areas directly pertinent to each trainee's research. This interdisciplinary training program draws on the expertise of faculty from three schools at Stanford University: the School of Humanities and Sciences, the School of Engineering, and the School of Medicine. The Program will train students at two levels: predoctoral and postdoctoral. Each trainee will have a preceptor in whose laboratory he/she will spend the vast majority of their time, and a co-mentor representing a disparate scientific discipline. Predoctoral and Postdoctoral Committees will oversee the selection and monitoring of their respective trainees. Once in the program, the trainees will receive complementary training in the areas with which they have no previous experience. For example, a predoctoral candidate in Developmental Biology will take courses in Bioengineering. Unless trainees already have an MD degree, they will undertake a two-week clinical immersion rotation to expose them to the consequences of organ and tissue deficiencies/dysfunction in areas directly related to their research. In addition to their scientific training, trainees will acquire the leadership skills necessary to direct interdisciplinary research groups in the future. Finally, because our trainees will have an interdisciplinary education that includes Developmental Biology, Bioengineering, and Clinical Medicine, it is anticipated that they will contribute to the development of novel therapies to regenerate, repair, and replace deficient or dysfunctional tissue and organs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Interdisciplinary Research Training Award (T90)
Project #
5T90DK070103-05
Application #
7483635
Study Section
Special Emphasis Panel (ZDK1-GRB-3 (O1))
Program Officer
Bishop, Terry Rogers
Project Start
2004-09-30
Project End
2009-11-30
Budget Start
2008-08-01
Budget End
2009-11-30
Support Year
5
Fiscal Year
2008
Total Cost
$357,552
Indirect Cost

  Institution

Name
Stanford University
Department
Surgery
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Bockhorn, Jessica; Yee, Kathy; Chang, Ya-Fang et al. (2013) MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. Breast Cancer Res Treat 137:373-82
Bockhorn, Jessica; Dalton, Rachel; Nwachukwu, Chika et al. (2013) MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun 4:1393
Sharma, Ved P; Beaty, Brian T; Patsialou, Antonia et al. (2012) Reconstitution of in vivo macrophage-tumor cell pairing and streaming motility on one-dimensional micro-patterned substrates. Intravital 1:77-85
Carpentier, Pamela A; Dingman, Andra L; Palmer, Theo D (2011) Placental TNF-ýý signaling in illness-induced complications of pregnancy. Am J Pathol 178:2802-10
Lahti, Jennifer L; Lui, Bertrand H; Beck, Stayce E et al. (2011) Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation. FEBS Lett 585:1135-9
Atmaja, Bayu; Lui, Bertrand H; Hu, Yuhua et al. (2010) Targeting of Cancer Cells Using Quantum Dot-Polypeptide Hybrid Assemblies that Function as Molecular Imaging Agents and Carrier Systems. Adv Funct Mater 20:4091-4097
Hammerick, Kyle E; Longaker, Michael T; Prinz, Fritz B (2010) In vitro effects of direct current electric fields on adipose-derived stromal cells. Biochem Biophys Res Commun 397:12-7
Jia, Fangjun; Wilson, Kitchener D; Sun, Ning et al. (2010) A nonviral minicircle vector for deriving human iPS cells. Nat Methods 7:197-9
Silverman, Adam P; Levin, Aron M; Lahti, Jennifer L et al. (2009) Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities. J Mol Biol 385:1064-75
Lahti, Jennifer L; Silverman, Adam P; Cochran, Jennifer R (2009) Interrogating and predicting tolerated sequence diversity in protein folds: application to E. elaterium trypsin inhibitor-II cystine-knot miniprotein. PLoS Comput Biol 5:e1000499

Showing the most recent 10 out of 12 publications