The overall goal of the NGEC is the application of genome engineering to hematopoietic stem cells forthe purpose of gene repair. Achieving this goal will require work among the seven NGEC scientificcomponents to be tightly integrated. A secondary aim of the NGEC is to promote the development ofgenome engineering as a scientific discipline. This T90/R90 component will function to promote both of theseobjectives by supporting interdisciplinary training of post-doctoral level individuals in genome engineering-related fields. Selected individuals will carry out projects spanning two or more disciplines with co-mentoring by twoprincipal investigators with complementary expertise. Support is requested for one position in year one, threepositions in year 2, and four positions in years 3-5. Fellows will be chosen on the basis of the interdisciplinarynature of their project and its relationship to genome engineering. The period of training will be up to twoyears, and training will involve active research and associated laboratory meetings, NGEC group meetings(see component 1), presentation of their data at the annual Workshop for Genome Engineering (seecomponent 9), and travel to an outside meeting each year. Options are also provided for additionalinterdisciplinary experiences including didactic coursework, a biotechnology externship, the manyinterdisciplinary symposia and workshops which take place among NGEC institutions, and graduate levelteaching.
| Kuhar, Ryan; Gwiazda, Kamila S; Humbert, Olivier et al. (2014) Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks. Nucleic Acids Res 42:e4 |
