The goal of the Mayo Clinic CTSA application is to present our vision for the integration and expansion of our innovative clinical and translational research activities, so that a highly functional academic home for cljnica! and translational research is developed at the Mayo Clinic. This new Center for'Clinical and Translational Research (CCTR) will be founded on Mayo's long-standing excellence in and commitment to clinical and translational research, which includes the support of key infrastructure and a commitment to career development. To achieve this goal we describe a comprehensive approach to the key elements of theCTSA RFA and focus on enhancing: 1) Clinical Research Core Resources that provide innovative tools to investigators; 2) Career Development and Education Programs that prepare the next generation of investigators; 3) Compliance and Regulatory Affairs Support that ensures patient safety and privacy, and customer service-oriented approaches to support investigative teams; 4) Community Affairs support to enhance participation, diversity and community support for clinical and translational research; 5) Collaboration with Industry and Clinical Practices to translate research discoveries into routine clinical practice; and 6) Continued and Expanded Institutional Support that includes an """"""""academic home"""""""" for clinical and translational research. We also propose a consolidated governance plan that incorporates strong data-driven evaluation of each CCTR element and the program as a whole. In principle, the CTSA program is consistent with the historical, conceptual and philosophical underpinnings of Mayo Clinic, and in this application we clearly articulate our vision of how the overarching and transformative goals of the CTSA program can be met at Mayo. Additionally, we have the """"""""institutional will"""""""" and are culturally empowered to execute our plan. Thus, Mayo is ready to implement the CTSA program aggressively and rapidly; the Mayo Clinic CCTR will be a highly functional and successful """"""""flagship"""""""" site for the CTSA program as it emerges from the NIHRoadmap. To summarize, the Mayo Clinic Center for Clinical and Translational Research (CCTR) will bring together all the resources of the five schools within the Mayo Clinic College of Medicine, and more than 100 years of scientific and medical research expertise, to discover innovative new methods that will speed the translation of research results into therapies, tools and patient care practices that impact all members of our local and national communities. This vision is entirely consistent with the stated mission of the Mayo Clinic to provide the best care to every patient every day.through integrated clinicalpractice, education and research.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Training Award (TL1)
Project #
5TL1RR024152-02
Application #
7294947
Study Section
Special Emphasis Panel (ZRR1-CR-A (01))
Program Officer
Rosenblum, Daniel
Project Start
2006-09-30
Project End
2011-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
2
Fiscal Year
2007
Total Cost
$331,628
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Jondal, Danielle E; Thompson, Scott M; Butters, Kim A et al. (2018) Heat Stress and Hepatic Laser Thermal Ablation Induce Hepatocellular Carcinoma Growth: Role of PI3K/mTOR/AKT Signaling. Radiology 288:730-738
Thompson, Scott M; Jondal, Danielle E; Butters, Kim A et al. (2018) Heat stress and thermal ablation induce local expression of nerve growth factor inducible (VGF) in hepatocytes and hepatocellular carcinoma: pre-clinical and clinical studies. Gene Expr :
Thompson, Scott M; Jondal, Danielle E; Butters, Kim A et al. (2018) Heat stress induced, ligand-independent MET and EGFR signalling in hepatocellular carcinoma. Int J Hyperthermia 34:812-823
Taylor, Bryan J; Snyder, Eric M; Richert, Maile L et al. (2017) Effect of ?2-adrenergic receptor stimulation on lung fluid in stable heart failure patients. J Heart Lung Transplant 36:418-426
Zakeri, Rosita; Burnett Jr, John C; Sangaralingham, S Jeson (2015) Urinary C-type natriuretic peptide: an emerging biomarker for heart failure and renal remodeling. Clin Chim Acta 443:108-13
Harvey, Ronee E; Barnes, Jill N; Charkoudian, Nisha et al. (2014) Forearm vasodilator responses to a ?-adrenergic receptor agonist in premenopausal and postmenopausal women. Physiol Rep 2:
Wu, Lang; Goldstein, Alisa M; Yu, Kai et al. (2014) Variants associated with susceptibility to pancreatic cancer and melanoma do not reciprocally affect risk. Cancer Epidemiol Biomarkers Prev 23:1121-4
Koep, Tyler H; Enders, Felicity T; Pierret, Chris et al. (2013) Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools. BMC Infect Dis 13:71
Taylor, Bryan J; Mojica, Cesar R; Olson, Thomas P et al. (2013) A possible role for systemic hypoxia in the reactive component of pulmonary hypertension in heart failure. J Card Fail 19:50-9
Greenberg, A J; Lee, A M; Serie, D J et al. (2013) Single-nucleotide polymorphism rs1052501 associated with monoclonal gammopathy of undetermined significance and multiple myeloma. Leukemia 27:515-6

Showing the most recent 10 out of 34 publications