Columbia University Medical Center's (CUMC) CTSA and Irving Institute for Clinical and Translational Research (IICTR), using the expertise and commitment of faculty in 10 Key Resources have made outstanding progress toward the goal of transforming the culture of clinical and translational (C/T) research at CUMC. Examples include: novel projects using interdisciplinary approaches;a novel, 2-phase interdisciplinary pilot award program that has already captured several NIH grants;a Website for all service request that also has a faculty directory that facilitates collaborative research;5 hours of free consultation to more than 600 investigators leading to 33 NIH grants and 106 publications;collaboration among several CUMC regulatory groups that has significantly improved contracting, IRB time-to-approval, and ethics education/consultation services;successful launch of satellites research facilities in ICUs and EDs resulting in 50 new investigators conducting 30 new protocols;opening ofthe Columbia Community Partnership for Health center, one-half mile from CUMC, as a home for community-based organizations and communitybased participatory research;launching of a new Master's degree in POR, a novel one year certificate curriculum within existing T32 programs, and an outstanding KL2 program with 9 scholars already capturing independent funding;and transformation of the """"""""old"""""""" GCRC core laboratory into a campus-wide biomarkers core serving T l , T2 and T3 investigators. Throughout, our Tracking and Evaluation Group has provided critical assistance regarding future direction. Most importantly, we have validated the concept of the CTSA and are changing the culture of research at CUMC. In the next 4 years, with institutional support of nearly $4 million yearly, we will build upon this foundation and (1) Expand the resources and infrastructure that we have developed forT2 and T3 clinical researchers;(2) Capitalize on CUMC's outstanding Tl discovery research community by integrating existing resources and investigators even more closely into our CTSA. (3) Improve the health of our community by working with the NYPH ambulatory care network and community based organizations to develop platforms for corriparative effectiveness research.
The Clinical and Translational Science Award (CTSA) allows Columbia University to support novel programs whose goal is to speed the translation of scientific discoveries made in the laboratory into new therapies. The CTSA will ensure that these new therapies are accepted by practicing physicians and community members so that we can begin to significantly improve the health of our community and nation.
| Crowe, Jennifer L; Shao, Zhengping; Wang, Xiaobin S et al. (2018) Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination. Proc Natl Acad Sci U S A 115:8615-8620 |
| Lee, Annie J; Wang, Yuanjia; Alcalay, Roy N et al. (2017) Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry. Mov Disord 32:1432-1438 |
| Olsen, Timothy R; Tapia-Alveal, Claudia; Yang, Kyung-Ae et al. (2017) INTEGRATED MICROFLUIDIC SELEX USING FREE SOLUTION ELECTROKINETICS. J Electrochem Soc 164:B3122-B3129 |
| Abate, Francesco; da Silva-Almeida, Ana C; Zairis, Sakellarios et al. (2017) Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas. Proc Natl Acad Sci U S A 114:764-769 |
| Olsen, Timothy; Zhu, Jing; Kim, Jinho et al. (2017) An Integrated Microfluidic SELEX Approach Using Combined Electrokinetic and Hydrodynamic Manipulation. SLAS Technol 22:63-72 |
| Lee, Annie J; Marder, Karen; Alcalay, Roy N et al. (2017) Estimation of genetic risk function with covariates in the presence of missing genotypes. Stat Med 36:3533-3546 |
| Boland, Mary Regina; Parhi, Pradipta; Gentine, Pierre et al. (2017) Climate Classification is an Important Factor in Assessing Quality-of-Care Across Hospitals. Sci Rep 7:4948 |
| Pappas, Kyrie; Xu, Jia; Zairis, Sakellarios et al. (2017) p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes. Mol Cancer Res 15:1051-1062 |
| Wang, Jiguang; Cazzato, Emanuela; Ladewig, Erik et al. (2016) Clonal evolution of glioblastoma under therapy. Nat Genet 48:768-76 |
| Kim, Jinho; Olsen, Timothy R; Zhu, Jing et al. (2016) Integrated Microfluidic Isolation of Aptamers Using Electrophoretic Oligonucleotide Manipulation. Sci Rep 6:26139 |
Showing the most recent 10 out of 22 publications
