We established the UCSF Clinical and Translational Science Institute (CTSI) at the University of California, San Francisco (UCSF) in 2006 to accelerate the pace of research that improves the health ofthe public. The overall mission of CTSI has been to improve and transform clinical and translational research infrastructure and training at UCSF and our partner institutions. In the next funding period we aim to use the substantial knowledge, skills, and infrastructure that we have developed to further accelerate the pace of research at UCSF, to export our successes to other institutions, and to create initiatives aimed at improving the health of our own and other communities, through the following aims:
SPECIFIC AIM 1 : To enhance the highly successful activities of the UCSF CTSI, including the development of new initiatives in the areas of Training, Jnfrastructure/Services, and Advocacy/Culture Change: a) Training: to provide programs for students at all levels, across a spectrum of settings, and including all phases of the improvement of healthcare;b) Infrastructure/Services: to expand services and tools to clinical and translational investigators at UCSF, our partner institutions, and within the broader regional, national, and global communities;and, c) Advocacy/Culture Change: to nurture communication, encourage collaboration, foster innovation, and catalyze the successful conduct of clinical and translational research;to support a diverse faculty;to increase involvement ofthe community and the responsive of research to its needs;and change the academic culture to promote multidisciplinary, collaborative work.
SPECIFIC AIM 2 : To develop crosscutting initiatives using the knowledge, skills, and infrastructure developed by multiple CTSI programs in the first funding period to accelerate clinical and translational research and its impact on health, well beyond the institutions collaborating in the UCSF CTSI. New initiatives will: a) Bring together local public health and philanthropic groups to work with CTSI to improve the health of the San Francisco Bay Area community through a series of health improvement projects directed at high impact conditions;b) create a model system to accelerate the pace of clinical and translational research that includes streamlining regulation, developing participant recruitment services, providing research management, and bringing research services directly into community practices;and, c) improve the performance, transparency and accountability of research administration within and jeyond CTSI by setting challenging goals and tracking performance metrics on public dashboards.
These aims will be achieved by orchestration of activities occurring within and between our 10 programs, supported by a proven governance model, and with strong ties to institutional and community leadership. Our ultimate goal is to bring better health to more people more quickly.
CTSI aims to bring better health to more people more quickly by supporting training, infrastructure, advocacy, and culture change. CTSI achieves this goal not by conducting research but by making it easier for UCSF's superb investigators to conduct research. The current infrastructure and policy environment for clinical and translational research is inefficient, cumbersome and even obstructionist, so CTSI can only meet its goals if it also transforms the way research is done. Its goal is to build innovative infrastructure, tools and services, to transform the core university culture to one which promotes and rewards collaboration and accelerate the clinical application of basic science.
| Scully, Kathleen M; Lahmy, Reyhaneh; Signaevskaia, Lia et al. (2018) E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53. Cell Mol Gastroenterol Hepatol 6:181-198 |
| Hojilla, J Carlo; Vlahov, David; Crouch, Pierre-Cedric et al. (2018) HIV Pre-exposure Prophylaxis (PrEP) Uptake and Retention Among Men Who Have Sex with Men in a Community-Based Sexual Health Clinic. AIDS Behav 22:1096-1099 |
| Hojilla, J Carlo; Mehrotra, Megha; Truong, Hong-Ha M et al. (2018) HIV sero disclosure among men who have sex with men and transgender women on HIV pre-exposure prophylaxis. AIDS Care 30:466-472 |
| Kunitake, Ryan C; Kornblith, Lucy Z; Cohen, Mitchell Jay et al. (2018) Trauma Early Mortality Prediction Tool (TEMPT) for assessing 28-day mortality. Trauma Surg Acute Care Open 3:e000131 |
| Kunitake, Ryan C; Howard, Benjamin M; Kornblith, Lucy Z et al. (2017) Individual clotting factor contributions to mortality following trauma. J Trauma Acute Care Surg 82:302-308 |
| Samoylova, Mariya L; Nigrini, Mark J; Dodge, Jennifer L et al. (2017) Biases in the reporting of hepatocellular carcinoma tumor sizes on the liver transplant waiting list. Hepatology 66:1144-1150 |
| Nguyen, Kaylin T; Olgin, Jeffrey E; Pletcher, Mark J et al. (2017) Smartphone-Based Geofencing to Ascertain Hospitalizations. Circ Cardiovasc Qual Outcomes 10: |
| Imber, Brandon S; Kanungo, Ishan; Braunstein, Steve et al. (2017) Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery 80:129-139 |
| Krishnan, A P; Karunamuni, R; Leyden, K M et al. (2017) Restriction Spectrum Imaging Improves Risk Stratification in Patients with Glioblastoma. AJNR Am J Neuroradiol 38:882-889 |
| Zygourakis, Corinna C; Imber, Brandon S; Chen, Rebecca et al. (2017) Cost-Effectiveness Analysis of Surgical versus Medical Treatment of Prolactinomas. J Neurol Surg B Skull Base 78:125-131 |
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