The University of Chicago (UC) Institute for Translational Medicine (ITM) was created in 2007 to assemble, integrate, and create the intellectual, administrative, and physical resources required to catalyze research and research training in Clinical and Translational Science. Its ultimate goals are to train scientists and health care providers at UC and in our community to determine the molecular, genetic, pathophysiologic and social determinants of disease and disease predisposition in individuals; to test interventions directed toward those mechanisms; and to achieve these goals in a way that is rigorous, efficient, ethical, respectful of, and responsive to our community's needs and values. In its first 4 years, the ITM has capitalized on the outstanding intellectual and physical resources throughout the University and at ITM affiliate Institutions, Argonne National Laboratory, NorthShore University HealthSystem, Illinois Institute of Technology, and Access Community Health Network, and on substantial institutional and CTSA financial investments, to build the infrastructure for a transformative, energized, and self-improving home for clinical and translational research. The impact of the ITM has been greatest in 5 domains: 1) catalyzing the formation of multidisciplinary research teams; 2) establishing a systematic, organized clinical and translational research infrastructure; 3) engaging our community in research; 4) training for careers in clinical and translational team science; and 5) impact on and contributions to the National CTSA Consortium. Building on these, we propose to expand research and training opportunities with five major initiatives: a new Tl Research and Technology Cluster; new Cores in Comparative Effectiveness Research and in Social, Environmental, and non-Biological Determinants of Health; a Personalizing Medicine initiative; a new Entrepreneurship Training and Support Program; and a Nurse-Scientist Training Program at new ITM affiliate Rush University. These programs, strengthened by community advice, engagement, partnership and participation, will ensure continued transformation of clinical and translational science at the University of Chicago and affiliates, on the South Side of Chicago, and beyond.
This program leverages the expertise of University of Chicago and affiliated investigators in a broad array of clinical and nonclinical fields to prepare the next generation of clinical and translational researchers to engage with our community partners to identify and prioritize a translational research agenda, and to address and reduce clinical health disparities in diverse adult and pediatric populations in our Community.
| Bryan, Ava F; Chor, Julie (2018) Factors Influencing Adolescent and Young Adults' First Pelvic Examination Experiences: A Qualitative Study. J Pediatr Adolesc Gynecol : |
| Bryan, Ava Ferguson; Chor, Julie (2018) Factors Influencing Young Women's Preparedness for Their First Pelvic Examination. Obstet Gynecol 132:479-486 |
| Miller, Melissa A; Bershad, Anya; King, Andrea C et al. (2016) Intranasal oxytocin dampens cue-elicited cigarette craving in daily smokers: a pilot study. Behav Pharmacol 27:697-703 |
| Bershad, Anya K; Seiden, Jacob A; de Wit, Harriet (2016) Effects of buprenorphine on responses to social stimuli in healthy adults. Psychoneuroendocrinology 63:43-9 |
| Bershad, Anya K; Weafer, Jessica J; Kirkpatrick, Matthew G et al. (2016) Oxytocin receptor gene variation predicts subjective responses to MDMA. Soc Neurosci 11:592-9 |
| Wardle, Margaret C; Bershad, Anya K; de Wit, Harriet (2016) Naltrexone alters the processing of social and emotional stimuli in healthy adults. Soc Neurosci 11:579-91 |
| Burrows, Michael P; Volchkov, Pavel; Kobayashi, Koichi S et al. (2015) Microbiota regulates type 1 diabetes through Toll-like receptors. Proc Natl Acad Sci U S A 112:9973-7 |
| Frankenberger, Casey; Rabe, Daniel; Bainer, Russell et al. (2015) Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages. Cancer Res 75:4063-73 |
| Chourasia, Aparajita H; Macleod, Kay F (2015) Tumor suppressor functions of BNIP3 and mitophagy. Autophagy 11:1937-8 |
| Chourasia, Aparajita H; Tracy, Kristin; Frankenberger, Casey et al. (2015) Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. EMBO Rep 16:1145-63 |
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