Abstract

TheUniversityofKentucky(UK)CenterforClinicalandTranslationalScience(CCTS)TrainingProgramin ClinicalandTranslationalScience(UKTL1program)willprepareprofessionalandpredoctoralstudentsto assumeleadershiprolestodirectteamscienceacrosstheclinicalandtranslationalresearch(CTR)spectrum. Overthelastfiveyears,theUKTL1programhasleveragedUK?sCTRstrengthstoprovideamultidisciplinary andtransdirectionaltrainingprogramthatintegratestraineesacrossdiversefieldstoprovidearigorousand solidresearcheducationinCTR.Withthisapproach,wehaveachievedourgoalofincreasingthenumberof investigatorswhobridgethegapbetweenbasicscienceadvancesandtheirapplicationtoclinicalmedicine. Thishasbeenaccomplishedbyprovidingahighlycollaborativetrainingenvironmentthatincubatesscholars andmentorswithaninnovativeandnurturingstructuretodevelopresearchcompetenciesinateam-based environment.Thesuccessoftraineesinthefirstfundingcycleandthedevelopmentofaninnovativetraining processtoengageevengreaternumbersofstudentsinCTRarethefoundationforthefollowingSpecific Aims:1)toincreasethepipelineofinvestigatorsengagedinCTR;?2)totrainacrossthespectrumofCTR;?and 3)topreparescholarstoparticipateeffectivelyinteamscience.Tomeetouraims,weproposetoincreasethe numberofpredoctoralTL1studentssupportedeachyearandtoincludeanew12-monthintensiveCTR experiencetomeetanidentifiedneedamongprofessionalstudentsandmedicalprofessionalsinresidency. Wewillcontinuetosolicitapplicationsbroadlyacrosscampus,offernewexperientialtrainingincommunity researchinruralpopulationsinCentralAppalachia,anddevelopdoctoral-leveltraininginbiomedical informatics,takingadvantageoftherecentinfluxofleadershipandexpertiseinthisareaatUK.Finally,wewill providetraineeswiththelatestskillsetstoparticipateeffectivelyininterdisciplinaryandcollaborativeteam science.Theseinitiativeswillacceleratethecareerdevelopmentoffutureleadersofthebiomedicalresearch workforcewhocanaddresstoday?scomplexresearchchallengesandspearheadadvancesinhumanhealth.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Training Award (TL1)
Project #
5TL1TR001997-04
Application #
9712983
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Brazhnik, Olga
Project Start
2016-08-15
Project End
2021-05-31
Budget Start
2019-06-01
Budget End
2021-05-31
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Kentucky
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40526

  Publications

Gupta, Vedant A; Leung, Steve W; Winkler, Michael A et al. (2018) Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans. J Vis Exp :
Brown, Christopher A; Jiang, Yang; Smith, Charles D et al. (2018) Age and Alzheimer's pathology disrupt default mode network functioning via alterations in white matter microstructure but not hyperintensities. Cortex 104:58-74
Bane, Maria; Brown, Megan; Angadi, Vrushali et al. (2018) Vocal function exercises for normal voice: With and without semi-occlusion. Int J Speech Lang Pathol :1-7
Stehouwer, Nathan; Okello, Emmy; Gupta, Vedant et al. (2018) Development and Validation of a Teaching Module for Echocardiographic Scoring of Rheumatic Mitral Stenosis. Glob Heart 13:105-111
Kline, Paul W; Burnham, Jeremy; Yonz, Michael et al. (2018) Hip external rotation strength predicts hop performance after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 26:1137-1144
Bane, Maria; Angadi, Vrushali; Dressler, Emily et al. (2017) Vocal function exercises for normal voice: The effects of varying dosage. Int J Speech Lang Pathol :1-9
Dong, Anping; Mueller, Paul; Yang, Fanmuyi et al. (2017) Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice. Thromb Res 159:58-64
Gold, Brian T; Brown, Christopher A; Hakun, Jonathan G et al. (2017) Clinically silent Alzheimer's and vascular pathologies influence brain networks supporting executive function in healthy older adults. Neurobiol Aging 58:102-111
Sinner, Gregory J; Gupta, Vedant A; Seratnahaei, Arash et al. (2017) Atrioventricular dyssynchrony from empiric device settings is common in cardiac resynchronization therapy and adversely impacts left ventricular morphology and function. Echocardiography 34:496-503
Spear, Tyler J; Stromp, Tori A; Leung, Steve W et al. (2017) Influence of longitudinal position on the evolution of steady-state signal in cardiac cine balanced steady-state free precession imaging. Acta Radiol Open 6:2058460117729186

Showing the most recent 10 out of 15 publications