It is estimated that Fetal Alcohol Spectrum Disorders (FASD) is the most common neurodevelopmental disability among children throughout the world. Furthering our understanding of the factors that potentially modify risk for FASD, continue to be critical gaps in research that could drive prevention and intervention strategies throughout the world. A longitudinal cohort sample has been established in Ukraine during the current funding period with detailed documentation of prenatal alcohol exposure, maternal nutritional status, and FASD outcomes. In this same sample a multimicronutrient supplement intervention trial has been implemented. During the renewal period, we propose to examine the persistence of and/or the novel manifestation of beneficial neurobehavioral effects of the prenatal multimicronutrient intervention trial, to examine the role of postnatal child nutrition in FASD, an to explore genetic and epigenetic factors as biomarkers of maternal exposure and risk modification among alcohol consuming pregnant women.

Public Health Relevance

Fetal Alcohol Spectrum Disorders (FASDs) are among the most common developmental disabilities throughout the world. Identification of effective methods for prevention and early intervention for FASD is critical. In a longitudinal study in Ukraine, earlier identification and prevention of FASD is being evaluated in four areas: a) the contribution of pre and postnatal nutritional factors to risk for FASD, b) development of a preschool neurobehavioral testing battery appropriate for early identification of affected children c) the utility of a novel and objective biomarker of exposure to alcohol, and d) exploration of genetic and epigenetic factors that may modify risk for FASD in mother/child pairs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project--Cooperative Agreements (U01)
Project #
4U01AA014835-13
Application #
9063018
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Dunty, Jr, William
Project Start
2003-09-30
Project End
2017-05-31
Budget Start
2016-06-01
Budget End
2017-05-31
Support Year
13
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Pediatrics
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Chan, Priscilla H; Xu, Ronghui; Chambers, Christina D (2018) A Study of R2 Measure under the Accelerated Failure Time Models. Commun Stat Simul Comput 47:380-391
Coles, Claire D; Kable, Julie A; Granovska, Irina V et al. (2018) Gestational age and socioeconomic status as mediators for the impact of prenatal alcohol exposure on development at 6?months. Birth Defects Res :
Sowell, K D; Uriu-Adams, J Y; Van de Water, J et al. (2018) Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure. Alcohol 68:49-58
Bodnar, Tamara S; Raineki, Charlis; Wertelecki, Wladimir et al. (2018) Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy. Brain Behav Immun 73:205-215
Carlson Jr, Charles R; Uriu-Adams, Janet Y; Chambers, Christina D et al. (2017) Vitamin D Deficiency in Pregnant Ukrainian Women: Effects of Alcohol Consumption on Vitamin D Status. J Am Coll Nutr 36:44-56
Mesa, Diego A; Kable, Julie A; Coles, Claire D et al. (2017) The Use of Cardiac Orienting Responses as an Early and Scalable Biomarker of Alcohol-Related Neurodevelopmental Impairment. Alcohol Clin Exp Res 41:128-138
Kable, Julie A; Coles, Claire D; Jones, Kenneth L et al. (2016) Cardiac Orienting Responses Differentiate the Impact of Prenatal Alcohol Exposure in Ukrainian Toddlers. Alcohol Clin Exp Res 40:2377-2384
Balaraman, Sridevi; Schafer, Jordan J; Tseng, Alexander M et al. (2016) Plasma miRNA Profiles in Pregnant Women Predict Infant Outcomes following Prenatal Alcohol Exposure. PLoS One 11:e0165081
Montag, Annika C; Hull, Andrew D; Yevtushok, Lyubov et al. (2016) Second-Trimester Ultrasound as a Tool for Early Detection of Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res 40:2418-2425
Coles, Claire D; Kable, Julie A; Keen, Carl L et al. (2015) Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants. Matern Child Health J 19:2605-14

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