Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01AG049508-01
Application #
8836777
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (J1))
Program Officer
Miller, Marilyn
Project Start
2014-06-15
Project End
2018-05-31
Budget Start
2014-06-15
Budget End
2015-05-31
Support Year
1
Fiscal Year
2014
Total Cost
$429,413
Indirect Cost
$147,831
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Raghavan, Neha S; Brickman, Adam M; Andrews, Howard et al. (2018) Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease. Ann Clin Transl Neurol 5:832-842
Pimenova, Anna A; Raj, Towfique; Goate, Alison M (2018) Untangling Genetic Risk for Alzheimer's Disease. Biol Psychiatry 83:300-310
Marioni, Riccardo E; Harris, Sarah E; Zhang, Qian et al. (2018) GWAS on family history of Alzheimer's disease. Transl Psychiatry 8:99
Blue, Elizabeth E; Bis, Joshua C; Dorschner, Michael O et al. (2018) Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dement Geriatr Cogn Disord 45:1-17
Blue, E E; Yu, C-E; Thornton, T A et al. (2018) Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease. Genes Brain Behav 17:e12429
Bis, Joshua C; Jian, Xueqiu; Kunkle, Brian W et al. (2018) Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol Psychiatry :
Efthymiou, Anastasia G; Goate, Alison M (2017) Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk. Mol Neurodegener 12:43
Haddick, Patrick C G; Larson, Jessica L; Rathore, Nisha et al. (2017) A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains. J Alzheimers Dis 56:1037-1054
Huang, Kuan-Lin; Marcora, Edoardo; Pimenova, Anna A et al. (2017) A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nat Neurosci 20:1052-1061
Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384

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